A1A2F7 (RSMH_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase H
EC=2.1.1.199

Alternative name(s):
16S rRNA m(4)C1402 methyltransferase
rRNA (cytosine-N(4)-)-methyltransferase RsmH

Gene names

Name:	rsmH
Synonyms:	mraW
Ordered Locus Names:	BAD_1109

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA By similarity. HAMAP MF_01007
Catalytic activity	S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. HAMAP MF_01007
Subcellular location	Cytoplasm By similarity HAMAP MF_01007.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmH family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Ribosomal RNA small subunit methyltransferase H HAMAP MF_01007		PRO_0000386745
Regions
	Region	39 – 41	3	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	58	1	S-adenosyl-L-methionine By similarity
	Binding site	87	1	S-adenosyl-L-methionine; via amide nitrogen By similarity
	Binding site	108	1	S-adenosyl-L-methionine By similarity
	Binding site	115	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1A2F7 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: F13543921505F5C1	FASTA	343	37,933
	10 20 30 40 50 60 MTDVTTIHQP VLLRDCVDLV APALAKPGSI AVDCTLGLAG HSTAFLKASP NARLIGIDRD 70 80 90 100 110 120 TEALALATKR MEMEGLADRF TPVHAAFDDF SQVLSDQGVD KVNAVFMDLG LSSLQIDETE 130 140 150 160 170 180 RGFSYSHDAP LDMRMDVTQP LTAEQVLAEY SFADLVRIFR AYGEERFSKQ IAREIVRRRE 190 200 210 220 230 240 TEPLTTSGQL NRLVDEVVPQ AHRPAGNPAK RVFQALRIEV NGELDKLAGT LPQIANHLAV 250 260 270 280 290 300 GGRLVVESYH SLEDKTVKAF MNQGLKVDAP ADMPVVPPDM MPFFKELTRG AIKADAEEIA 310 320 330 340 NNPRSASVRL RAVELTRPIP ARWRKRFDQG ADYASMTRQG RRD

References

[1]

"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009256 Genomic DNA. Translation: BAF39890.1.
RefSeq	YP_909972.1. NC_008618.1.
3D structure databases
ProteinModelPortal	A1A2F7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1A2F7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4556419.
GenomeReviews	Gene locus BAD_1109 in contig AP009256_GR.
KEGG	bad:BAD_1109.
NMPDR	fig|1680.3.peg.132.
PATRIC	21101649. VBIBifAdo27973_1188.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0275.
HOGENOM	HBG302779.
OMA	NPATRAF.
ProtClustDB	PRK00050.
Family and domain databases
HAMAP	MF_01007. 16SrRNA_methyltr_H. [Tree]
InterPro	IPR002903. SAM-dep_MeTrfase_MraW. IPR023397. SAM-dep_MeTrfase_MraW_recog. [Graphical view]
Gene3D	G3DSA:1.10.150.170. G3DSA:1.10.150.170. 1 hit.
KO	K03438.
PANTHER	PTHR11265. Bact_methyltrans. 1 hit.
Pfam	PF01795. Methyltransf_5. 1 hit. [Graphical view]
PIRSF	PIRSF004486. MraW. 1 hit.
SUPFAM	SSF81799. SSF81799. 1 hit.
TIGRFAMs	TIGR00006. TIGR00006. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RSMH_BIFAA

Accession

Primary (citable) accession number: A1A2F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program