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A1A2F2 (MRAY_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BAD_1104
OrganismBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]
Taxonomic identifier367928 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002939

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane51 – 7121Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane234 – 25421Helical; Potential
Transmembrane256 – 27621Helical; Potential
Transmembrane287 – 30923Helical; Potential
Transmembrane340 – 36021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1A2F2 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 895EA5560B470C4D

FASTA36540,081
        10         20         30         40         50         60 
MISLIIGIMV SLVVTIVGTP LLIKLVHKLN YGQYIRQDGP KSHLVKRGTP TLGGVVINLA 

        70         80         90        100        110        120 
VVLGWCSSAL YRFLTRGEVP SWSAVLVLFA MLSMGFLGFI DDFAKVRKKQ SEGLTVKGKF 

       130        140        150        160        170        180 
IGQFILATIY AVLALILPTK SGFPSAQAGM SFIEKPFFSF EFAGRVVAIV LFVIWVNFLM 

       190        200        210        220        230        240 
TAWTNAINLT DGLDGLAAGS SMIAFIGYAI IAFWEFYHLK GSDHPGFTYA VSDPLDLTII 

       250        260        270        280        290        300 
AACAAVACFG FLWYNSNPAS IFMGDTGSLA LGGLFAAMSI ATHTEFLAII LGGLFVIETM 

       310        320        330        340        350        360 
SDIIQVGYFK MTHKRVFKMA PIHHHFELKG WPEVKVVVRF WMIEMLFVLI ALVLFYGDWV 


ARSGL

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References

[1]"Bifidobacterium adolescentis complete genome sequence."
Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009256 Genomic DNA. Translation: BAF39885.1.
RefSeqYP_909967.1. NC_008618.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1A2F2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4556380.
GenomeReviewsGene locus BAD_1104 in contig AP009256_GR.
KEGGbad:BAD_1104.
NMPDRfig|1680.3.peg.140.
PATRIC21101639. VBIBifAdo27973_1183.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMAQVGYFKW.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. False negative.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BIFAA
AccessionPrimary (citable) accession number: A1A2F2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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