Reviewed, UniProtKB/Swiss-Prot A1A2E9 (MURG_BIFAA)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
    EC=2.4.1.227
Alternative name(s):
    Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase

Gene names

Name:	murG
Ordered Locus Names:	BAD_1101

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity.
Catalytic activity	UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 28 family. MurG subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW lipid glycosylation Inferred from electronic annotation. Source: HAMAP peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	carbohydrate binding Inferred from electronic annotation. Source: InterPro undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033		PRO_0000315072

Sequences

	Sequence		Length	Mass (Da)
	A1A2E9-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 9CA701E6784F80FF	FASTA	393	41,547
	10 20 30 40 50 60 MSNQKHIVLA GGGTAGHVNP LLAVAHVIRE LEPEADIAVV GTAVGLERDL VPQAGFELET 70 80 90 100 110 120 IEKVPFPRRP NKAALQFPAK WKAEKAKVRD ILTRHQAQVV VGFGGYTSAP VYAAAHSMGI 130 140 150 160 170 180 PIAIHEQNAR AGMANKLGAR WASMIGAAYA QPGLKPRRGV EVERVGLPLR PAIARLASDL 190 200 210 220 230 240 EHDRTATRKA AAAQLGVDPD RPLVVITGGS LGAVNVNRAV AASAKDLLAH AQVIHLTGKG 250 260 270 280 290 300 KDDEVRSLVS VSAGEDVLGE LGPDHVSDGD YRVAPYLERI DLAFACADLI ICRSGAGTVS 310 320 330 340 350 360 ELTALGLPAI YVPLPIGNGE QRFNAQPVVD AEGGLMVADG DFTPDWVRGH VPELLADPDK 370 380 390 LSRYGANAWK YGIRDAAEVM AKRVLALIDQ PAD

References

[1]	"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009256 Genomic DNA. Translation: BAF39882.1.
RefSeq	YP_909964.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1A2E9.
Genome annotation databases
GeneID	4556378.
GenomeReviews	Gene locus BAD_1101 in contig AP009256_GR.
KEGG	bad:BAD_1101.
NMPDR	fig|1680.3.peg.123.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PHGNGEQ.
Family and domain databases
HAMAP	MF_00033. [Tree]
InterPro	IPR004276. Glyco_trans_28. IPR007235. Glyco_trans_28_C. [Graphical view]
Pfam	PF04101. Glyco_tran_28_C. 1 hit. PF03033. Glyco_transf_28. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURG_BIFAA

Accession

Primary (citable) accession number: A1A2E9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)