Reviewed, UniProtKB/Swiss-Prot A1A1X1 (ARGB_BIFAA)

Names and origin

Protein names

Recommended name:
    Acetylglutamate kinase
    EC=2.7.2.8
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate 5-phosphotransferase

Gene names

Name:	argB
Ordered Locus Names:	BAD_0923

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Acetylglutamate kinase HAMAP MF_00082		PRO_0000335610
Regions
	Region	80 – 81	2	Substrate binding By similarity
Sites
	Binding site	102	1	Substrate By similarity
	Binding site	203	1	Substrate By similarity
	Site	45	1	Transition state stabilizer By similarity
	Site	264	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1A1X1-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 814839384EBCE243	FASTA	318	33,820
	10 20 30 40 50 60 MAKELKGPGF HFDVHTDLRA DQKAEVLIEA LPWLEEFAGQ RIVIKYGGNA MIDDHLKACF 70 80 90 100 110 120 AEDMVFLRQV GLHPVVVHGG GPQISQMLKA LGIKSEFKGG LRVTTPEAMD VVRMVLTGKV 130 140 150 160 170 180 SRELVGLINA HGPFAVGLSG EDGALFSAMQ RKPVIDGKPT DIGLVGDVVS VDASAVEDLI 190 200 210 220 230 240 NAGRIPVVSS VAPNEDDATE VLNVNADSAA AALAAALGAS KLVVLTDVDG LYADWPDRDS 250 260 270 280 290 300 LIGRIGVENL RDMLPDLESG MRPKMEACVR AIDGGVPRAH IIDGRKPHSI LNEIFTTDGI 310 GTMVVPEDGI EMRSSYGN

References

[1]	"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009256 Genomic DNA. Translation: BAF39704.1.
RefSeq	YP_909786.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1A1X1.
Genome annotation databases
GeneID	4557389.
GenomeReviews	Gene locus BAD_0923 in contig AP009256_GR.
KEGG	bad:BAD_0923.
NMPDR	fig|1680.3.peg.1194.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FVIKYGG.
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. IPR001057. Glu_5kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BIFAA

Accession

Primary (citable) accession number: A1A1X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)