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A1A1W7

- ASSY_BIFAA

UniProt

A1A1W7 - ASSY_BIFAA

Protein

Argininosuccinate synthase

Gene

argG

Organism
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei95 – 951CitrullineUniRule annotation
    Binding sitei125 – 1251ATP; via amide nitrogenUniRule annotation
    Binding sitei127 – 1271AspartateUniRule annotation
    Binding sitei131 – 1311AspartateUniRule annotation
    Binding sitei131 – 1311CitrullineUniRule annotation
    Binding sitei132 – 1321AspartateUniRule annotation
    Binding sitei135 – 1351CitrullineUniRule annotation
    Binding sitei183 – 1831CitrullineUniRule annotation
    Binding sitei267 – 2671CitrullineUniRule annotation
    Binding sitei279 – 2791CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 249ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBADO367928:GHPT-966-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:BAD_0919
    OrganismiBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
    Taxonomic identifieri367928 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000008702: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Argininosuccinate synthasePRO_0000321303Add
    BLAST

    Proteomic databases

    PRIDEiA1A1W7.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi367928.BAD_0919.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A1W7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiKANALYM.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A1W7-1 [UniParc]FASTAAdd to Basket

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    MLERETMSDQ NRLVLAYSGG LDTSVAISYL KERTGKDVVA VSLDVGQGGE    50
    SLETIKQRAL ACGAVEAYVV DARDEFANEY CMKALKANAM YEGVYPLVSA 100
    ISRPLISKHL VRAAHQFGAD TISHGCTGKG NDQVRFEVSI ASIDPTLKAI 150
    SPIRDLSLTR DVEIAFAKEH KLPIVQTEKS PFSIDQNVWG RAIETGFLED 200
    PWNGPTKDCY SYTDDPAFPP VEDEVVIEFK QGVPVKIDGH DVTPLQAIEE 250
    MNRRAGAQGI GRIDLIEDRL VGIKSRELYE APGAVALITA HQELENCCLE 300
    REQHRIKRDI DKRWAELVYD AQWFSPATQS LNAFIEDTQK YVSGEIRMVL 350
    HGGRAVVTGR RSDSSLYDYN LATYDSGDSF DQKSSNGFID IYGLPSRVAA 400
    ARDVKFGNGI EVPENSVE 418
    Length:418
    Mass (Da):46,215
    Last modified:January 23, 2007 - v1
    Checksum:iB45E1C9422333537
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009256 Genomic DNA. Translation: BAF39700.1.
    RefSeqiYP_909782.1. NC_008618.1.

    Genome annotation databases

    EnsemblBacteriaiBAF39700; BAF39700; BAD_0919.
    GeneIDi4557393.
    KEGGibad:BAD_0919.
    PATRICi21101263. VBIBifAdo27973_0995.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009256 Genomic DNA. Translation: BAF39700.1 .
    RefSeqi YP_909782.1. NC_008618.1.

    3D structure databases

    ProteinModelPortali A1A1W7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 367928.BAD_0919.

    Proteomic databases

    PRIDEi A1A1W7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF39700 ; BAF39700 ; BAD_0919 .
    GeneIDi 4557393.
    KEGGi bad:BAD_0919.
    PATRICi 21101263. VBIBifAdo27973_0995.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi KANALYM.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci BADO367928:GHPT-966-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bifidobacterium adolescentis complete genome sequence."
      Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

    Entry informationi

    Entry nameiASSY_BIFAA
    AccessioniPrimary (citable) accession number: A1A1W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3