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A1A1W7

- ASSY_BIFAA

UniProt

A1A1W7 - ASSY_BIFAA

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Protein
Argininosuccinate synthase
Gene
argG, BAD_0919
Organism
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Citrulline By similarity
Binding sitei125 – 1251ATP; via amide nitrogen By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei131 – 1311Aspartate By similarity
Binding sitei131 – 1311Citrulline By similarity
Binding sitei132 – 1321Aspartate By similarity
Binding sitei135 – 1351Citrulline By similarity
Binding sitei183 – 1831Citrulline By similarity
Binding sitei267 – 2671Citrulline By similarity
Binding sitei279 – 2791Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 249ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBADO367928:GHPT-966-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:BAD_0919
OrganismiBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Taxonomic identifieri367928 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000008702: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Argininosuccinate synthaseUniRule annotation
PRO_0000321303Add
BLAST

Proteomic databases

PRIDEiA1A1W7.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi367928.BAD_0919.

Structurei

3D structure databases

ProteinModelPortaliA1A1W7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiKANALYM.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A1W7-1 [UniParc]FASTAAdd to Basket

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MLERETMSDQ NRLVLAYSGG LDTSVAISYL KERTGKDVVA VSLDVGQGGE    50
SLETIKQRAL ACGAVEAYVV DARDEFANEY CMKALKANAM YEGVYPLVSA 100
ISRPLISKHL VRAAHQFGAD TISHGCTGKG NDQVRFEVSI ASIDPTLKAI 150
SPIRDLSLTR DVEIAFAKEH KLPIVQTEKS PFSIDQNVWG RAIETGFLED 200
PWNGPTKDCY SYTDDPAFPP VEDEVVIEFK QGVPVKIDGH DVTPLQAIEE 250
MNRRAGAQGI GRIDLIEDRL VGIKSRELYE APGAVALITA HQELENCCLE 300
REQHRIKRDI DKRWAELVYD AQWFSPATQS LNAFIEDTQK YVSGEIRMVL 350
HGGRAVVTGR RSDSSLYDYN LATYDSGDSF DQKSSNGFID IYGLPSRVAA 400
ARDVKFGNGI EVPENSVE 418
Length:418
Mass (Da):46,215
Last modified:January 23, 2007 - v1
Checksum:iB45E1C9422333537
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009256 Genomic DNA. Translation: BAF39700.1.
RefSeqiYP_909782.1. NC_008618.1.

Genome annotation databases

EnsemblBacteriaiBAF39700; BAF39700; BAD_0919.
GeneIDi4557393.
KEGGibad:BAD_0919.
PATRICi21101263. VBIBifAdo27973_0995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009256 Genomic DNA. Translation: BAF39700.1 .
RefSeqi YP_909782.1. NC_008618.1.

3D structure databases

ProteinModelPortali A1A1W7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 367928.BAD_0919.

Proteomic databases

PRIDEi A1A1W7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF39700 ; BAF39700 ; BAD_0919 .
GeneIDi 4557393.
KEGGi bad:BAD_0919.
PATRICi 21101263. VBIBifAdo27973_0995.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi KANALYM.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci BADO367928:GHPT-966-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bifidobacterium adolescentis complete genome sequence."
    Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Entry informationi

Entry nameiASSY_BIFAA
AccessioniPrimary (citable) accession number: A1A1W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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