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A1A1R2

- SYL_BIFAA

UniProt

A1A1R2 - SYL_BIFAA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei766 – 7661ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBADO367928:GHPT-909-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BAD_0864
OrganismiBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Taxonomic identifieri367928 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000008702: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 990990Leucine--tRNA ligasePRO_0000334732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi367928.BAD_0864.

Structurei

3D structure databases

ProteinModelPortaliA1A1R2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi74 – 8512"HIGH" regionAdd
BLAST
Motifi763 – 7675"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A1R2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTEKSAQA QPNESAEPSF RYNAKLAQGI EEKWQKIWDD EGTFWAANVN
60 70 80 90 100
GDLKDGKGHN AEGRPSYFAM DMFPYPSGKG LHVGHPLGYL ATDVVSRYHR
110 120 130 140 150
MKGENVLHAM GYDAFGLPAE QYAVQTGQHP RITTEQNIAN MRRQLHRMGL
160 170 180 190 200
SFDNRRSFAT IDPGYVRWTQ WIFSRIYDAW YDEDATNPSG SRGCARPIST
210 220 230 240 250
LVEQFESGKR AIPGFEGKAW ADLSEAEQAD VLNDFRLAYI SKSPVNWCPG
260 270 280 290 300
LGTVLANEEV TAEGKSERGN FPVFQRELRQ WSMRITAYGH RLIEDLDTID
310 320 330 340 350
WPEKVKLMQR NWIGESHGAS VHFDVETPNG VKDMEIYTTR PDTLFGTTFA
360 370 380 390 400
VVSPEHHLLE DVPAEWPAET PEDWKGGYAT PVEAVKAYRL AAEAKTAKDR
410 420 430 440 450
VDEAGEKTGL FTGLYAINPI TGAKLPLFTA DYVLMDYGTG AIMAVPGGDQ
460 470 480 490 500
RDYDFAVKFG LPVIYTVKPL PESGDDLANY EGKAPFVSHD GIVINSSIDA
510 520 530 540 550
TKAKGDSLSL DGLRVDEAID KVNAWLESAG VGKGTVSYRL RDWLFSRQRY
560 570 580 590 600
WGEPFPIVYG EDGTPHLLPD EQLPINLPDV PDYSPKTFDP EDAESDPEAP
610 620 630 640 650
LSRNEDWVKV ELDLGDGKKT YYRDTNTMPN WAGSCWYYMR YLDPTDTKHM
660 670 680 690 700
VEKDEFDYWM GPDHNKTAGK SGGVDLYIGG VEHAVLHLLY SRFWHKVLFD
710 720 730 740 750
LGYVDSMEPF HKLFNQGMIQ AYAYTDDRGQ YVPAAEVVEG PADANGEPTF
760 770 780 790 800
TWNGQHANRE FGKMGKSLKN IITPDDMYEN YGADTFRLYE MGMGPLAESR
810 820 830 840 850
PWNTRNVVGS MRFLQRLWRN VIDETTGEVR VTDGELDTKT LKLLNNTIAD
860 870 880 890 900
VTVEMEAMRP NTAIAKLIVL NNHLTSLDAV PRAAVEPLIL MLSPIAPHIC
910 920 930 940 950
EELWSKLGHT ESLAHADWPK ADERYVGQDS VTAVVQIKGK VRAKLEVSPD
960 970 980 990
IDPKELEKMA LEAVADRLGG KEPRKVIVKA PKIVSIVPAE
Length:990
Mass (Da):110,940
Last modified:January 23, 2007 - v1
Checksum:iD87EB57E09014058
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009256 Genomic DNA. Translation: BAF39645.1.
RefSeqiWP_011743229.1. NC_008618.1.
YP_909727.1. NC_008618.1.

Genome annotation databases

EnsemblBacteriaiBAF39645; BAF39645; BAD_0864.
GeneIDi4556281.
KEGGibad:BAD_0864.
PATRICi21101143. VBIBifAdo27973_0937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009256 Genomic DNA. Translation: BAF39645.1 .
RefSeqi WP_011743229.1. NC_008618.1.
YP_909727.1. NC_008618.1.

3D structure databases

ProteinModelPortali A1A1R2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 367928.BAD_0864.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF39645 ; BAF39645 ; BAD_0864 .
GeneIDi 4556281.
KEGGi bad:BAD_0864.
PATRICi 21101143. VBIBifAdo27973_0937.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BADO367928:GHPT-909-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bifidobacterium adolescentis complete genome sequence."
    Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Entry informationi

Entry nameiSYL_BIFAA
AccessioniPrimary (citable) accession number: A1A1R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3