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A1A1R2 (SYL_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BAD_0864
OrganismBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]
Taxonomic identifier367928 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length990 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 990990Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334732

Regions

Motif74 – 8512"HIGH" region HAMAP-Rule MF_00049
Motif763 – 7675"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7661ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1A1R2 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: D87EB57E09014058

FASTA990110,940
        10         20         30         40         50         60 
MSDTEKSAQA QPNESAEPSF RYNAKLAQGI EEKWQKIWDD EGTFWAANVN GDLKDGKGHN 

        70         80         90        100        110        120 
AEGRPSYFAM DMFPYPSGKG LHVGHPLGYL ATDVVSRYHR MKGENVLHAM GYDAFGLPAE 

       130        140        150        160        170        180 
QYAVQTGQHP RITTEQNIAN MRRQLHRMGL SFDNRRSFAT IDPGYVRWTQ WIFSRIYDAW 

       190        200        210        220        230        240 
YDEDATNPSG SRGCARPIST LVEQFESGKR AIPGFEGKAW ADLSEAEQAD VLNDFRLAYI 

       250        260        270        280        290        300 
SKSPVNWCPG LGTVLANEEV TAEGKSERGN FPVFQRELRQ WSMRITAYGH RLIEDLDTID 

       310        320        330        340        350        360 
WPEKVKLMQR NWIGESHGAS VHFDVETPNG VKDMEIYTTR PDTLFGTTFA VVSPEHHLLE 

       370        380        390        400        410        420 
DVPAEWPAET PEDWKGGYAT PVEAVKAYRL AAEAKTAKDR VDEAGEKTGL FTGLYAINPI 

       430        440        450        460        470        480 
TGAKLPLFTA DYVLMDYGTG AIMAVPGGDQ RDYDFAVKFG LPVIYTVKPL PESGDDLANY 

       490        500        510        520        530        540 
EGKAPFVSHD GIVINSSIDA TKAKGDSLSL DGLRVDEAID KVNAWLESAG VGKGTVSYRL 

       550        560        570        580        590        600 
RDWLFSRQRY WGEPFPIVYG EDGTPHLLPD EQLPINLPDV PDYSPKTFDP EDAESDPEAP 

       610        620        630        640        650        660 
LSRNEDWVKV ELDLGDGKKT YYRDTNTMPN WAGSCWYYMR YLDPTDTKHM VEKDEFDYWM 

       670        680        690        700        710        720 
GPDHNKTAGK SGGVDLYIGG VEHAVLHLLY SRFWHKVLFD LGYVDSMEPF HKLFNQGMIQ 

       730        740        750        760        770        780 
AYAYTDDRGQ YVPAAEVVEG PADANGEPTF TWNGQHANRE FGKMGKSLKN IITPDDMYEN 

       790        800        810        820        830        840 
YGADTFRLYE MGMGPLAESR PWNTRNVVGS MRFLQRLWRN VIDETTGEVR VTDGELDTKT 

       850        860        870        880        890        900 
LKLLNNTIAD VTVEMEAMRP NTAIAKLIVL NNHLTSLDAV PRAAVEPLIL MLSPIAPHIC 

       910        920        930        940        950        960 
EELWSKLGHT ESLAHADWPK ADERYVGQDS VTAVVQIKGK VRAKLEVSPD IDPKELEKMA 

       970        980        990 
LEAVADRLGG KEPRKVIVKA PKIVSIVPAE 

« Hide

References

[1]"Bifidobacterium adolescentis complete genome sequence."
Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009256 Genomic DNA. Translation: BAF39645.1.
RefSeqYP_909727.1. NC_008618.1.

3D structure databases

ProteinModelPortalA1A1R2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING367928.BAD_0864.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF39645; BAF39645; BAD_0864.
GeneID4556281.
KEGGbad:BAD_0864.
PATRIC21101143. VBIBifAdo27973_0937.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycBADO367928:GHPT-909-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BIFAA
AccessionPrimary (citable) accession number: A1A1R2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries