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A1A1R2

- SYL_BIFAA

UniProt

A1A1R2 - SYL_BIFAA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei766 – 7661ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBADO367928:GHPT-909-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BAD_0864
    OrganismiBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
    Taxonomic identifieri367928 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000008702: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 990990Leucine--tRNA ligasePRO_0000334732Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi367928.BAD_0864.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A1R2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi74 – 8512"HIGH" regionAdd
    BLAST
    Motifi763 – 7675"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A1R2-1 [UniParc]FASTAAdd to Basket

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    MSDTEKSAQA QPNESAEPSF RYNAKLAQGI EEKWQKIWDD EGTFWAANVN    50
    GDLKDGKGHN AEGRPSYFAM DMFPYPSGKG LHVGHPLGYL ATDVVSRYHR 100
    MKGENVLHAM GYDAFGLPAE QYAVQTGQHP RITTEQNIAN MRRQLHRMGL 150
    SFDNRRSFAT IDPGYVRWTQ WIFSRIYDAW YDEDATNPSG SRGCARPIST 200
    LVEQFESGKR AIPGFEGKAW ADLSEAEQAD VLNDFRLAYI SKSPVNWCPG 250
    LGTVLANEEV TAEGKSERGN FPVFQRELRQ WSMRITAYGH RLIEDLDTID 300
    WPEKVKLMQR NWIGESHGAS VHFDVETPNG VKDMEIYTTR PDTLFGTTFA 350
    VVSPEHHLLE DVPAEWPAET PEDWKGGYAT PVEAVKAYRL AAEAKTAKDR 400
    VDEAGEKTGL FTGLYAINPI TGAKLPLFTA DYVLMDYGTG AIMAVPGGDQ 450
    RDYDFAVKFG LPVIYTVKPL PESGDDLANY EGKAPFVSHD GIVINSSIDA 500
    TKAKGDSLSL DGLRVDEAID KVNAWLESAG VGKGTVSYRL RDWLFSRQRY 550
    WGEPFPIVYG EDGTPHLLPD EQLPINLPDV PDYSPKTFDP EDAESDPEAP 600
    LSRNEDWVKV ELDLGDGKKT YYRDTNTMPN WAGSCWYYMR YLDPTDTKHM 650
    VEKDEFDYWM GPDHNKTAGK SGGVDLYIGG VEHAVLHLLY SRFWHKVLFD 700
    LGYVDSMEPF HKLFNQGMIQ AYAYTDDRGQ YVPAAEVVEG PADANGEPTF 750
    TWNGQHANRE FGKMGKSLKN IITPDDMYEN YGADTFRLYE MGMGPLAESR 800
    PWNTRNVVGS MRFLQRLWRN VIDETTGEVR VTDGELDTKT LKLLNNTIAD 850
    VTVEMEAMRP NTAIAKLIVL NNHLTSLDAV PRAAVEPLIL MLSPIAPHIC 900
    EELWSKLGHT ESLAHADWPK ADERYVGQDS VTAVVQIKGK VRAKLEVSPD 950
    IDPKELEKMA LEAVADRLGG KEPRKVIVKA PKIVSIVPAE 990
    Length:990
    Mass (Da):110,940
    Last modified:January 23, 2007 - v1
    Checksum:iD87EB57E09014058
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009256 Genomic DNA. Translation: BAF39645.1.
    RefSeqiWP_011743229.1. NC_008618.1.
    YP_909727.1. NC_008618.1.

    Genome annotation databases

    EnsemblBacteriaiBAF39645; BAF39645; BAD_0864.
    GeneIDi4556281.
    KEGGibad:BAD_0864.
    PATRICi21101143. VBIBifAdo27973_0937.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009256 Genomic DNA. Translation: BAF39645.1 .
    RefSeqi WP_011743229.1. NC_008618.1.
    YP_909727.1. NC_008618.1.

    3D structure databases

    ProteinModelPortali A1A1R2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 367928.BAD_0864.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF39645 ; BAF39645 ; BAD_0864 .
    GeneIDi 4556281.
    KEGGi bad:BAD_0864.
    PATRICi 21101143. VBIBifAdo27973_0937.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BADO367928:GHPT-909-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bifidobacterium adolescentis complete genome sequence."
      Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

    Entry informationi

    Entry nameiSYL_BIFAA
    AccessioniPrimary (citable) accession number: A1A1R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3