Reviewed, UniProtKB/Swiss-Prot A1A1Q5 (GCP_BIFAA)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	BAD_0857

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303280
Sites
	Metal binding	113	1	Zinc Potential
	Metal binding	117	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	A1A1Q5-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: D55D37B4823A57FD	FASTA	347	36,127
	10 20 30 40 50 60 MSEPIVLGIE STCDETAAAV VQGRTLISNV VASSMDEHAR YGGVIPEIAS RAHAEAFVPC 70 80 90 100 110 120 VSKALADANM TLSDVDAIAV SAGPGLAGCL AVGVSGAKSL AWAANKPIYG INHVIGHIAV 130 140 150 160 170 180 TQLQFGPFPK DTLALIVSGG HTSLLHVEDV ARHIDVVGTT LDDAAGECFD KVARLLGFPY 190 200 210 220 230 240 PGGPHIDRHA QLGNPHAIKV PQGLTQGKAG QQHPYDFSFS GVKTAVARWI EQQQAEGNEI 250 260 270 280 290 300 PIDDVCASLA DSVATVLARK AMRGCEQYGS KTLIVGGGFS ANSQLRAKLL EVGAKHGVEV 310 320 330 340 RIPQIKLCTD NGAMVAMLGV NLVESGVKPS EPDFAIDSAM PLTKISM

References

[1]	"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009256 Genomic DNA. Translation: BAF39638.1.
RefSeq	YP_909720.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1A1Q5.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	4557249.
GenomeReviews	Gene locus BAD_0857 in contig AP009256_GR.
KEGG	bad:BAD_0857.
NMPDR	fig|1680.3.peg.1495.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EHSAYGG.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BIFAA

Accession

Primary (citable) accession number: A1A1Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)