A1A1M3 (UPPP_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA
Ordered Locus Names:	BAD_0825

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium › Bifidobacterium adolescentis

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000290688
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	123 – 143	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	234 – 254	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A1A1M3 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 805B72AE72D40D01	FASTA	294	31,596
	10 20 30 40 50 60 MNFFQAIFLG LVQALTEYLP VSSSAHIRII GDLMLGSDPG AAFTAIIQIG TELAVILYFR 70 80 90 100 110 120 HDIIRILGAW FGSLFGKEGK DFKSRMGAHN RDTQMGWFII IGTLPILIAG LLFKDAIEST 130 140 150 160 170 180 LRNLWITVTV LIIFGILLWV VDARAKQVKT MDEMTWKDAL IFGIGQMLAL IPGVSRSGGT 190 200 210 220 230 240 ITFGRAMGYT REAAVRVSFL MAIPAVFGAG ILEAVSAVKD VAAGNAGMFP GWGATIAATI 250 260 270 280 290 VAFVVGYVVI IGFLKFVSTF SYKAFAIYRI ALAVVVALLL ICGVLHPTEV VAAA

References

[1]

"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009256 Genomic DNA. Translation: BAF39606.1.
RefSeq	YP_909688.1. NC_008618.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	367928.BAD_0825.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAF39606; BAF39606; BAD_0825.
GeneID	4557546.
KEGG	bad:BAD_0825.
PATRIC	21101055. VBIBifAdo27973_0895.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	HLAIFTA.
ProtClustDB	PRK12554.
Enzyme and pathway databases
BioCyc	BADO367928:GHPT-895-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_BIFAA

Accession

Primary (citable) accession number: A1A1M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program