Reviewed, UniProtKB/Swiss-Prot A1A1K5 (APT_BIFAA)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase
      Short name=APRT
    EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	BAD_0807

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_1000000258

Sequences

	Sequence		Length	Mass (Da)
	A1A1K5-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: A615646DA87CAA2F	FASTA	193	20,237
	10 20 30 40 50 60 MAASDITVSG LNKVGAEDAA YLVSKIRTIP GFPKEGILFR DFMPVLADAR AFGILMGALE 70 80 90 100 110 120 AALPVDVDDF DMVVGLEARG FLFGPALAAR LGKGFIAVRK AGKLPPETMS QSYDLEYGQA 130 140 150 160 170 180 SMEIETNVVH EGVRVLIVDD LIATGGTANA ARSLIEKCGG VVAGFSFVME LTGIDGMKSL 190 GDYPTSSLVC MPA

References

[1]	"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009256 Genomic DNA. Translation: BAF39588.1.
RefSeq	YP_909670.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1A1K5.
Genome annotation databases
GeneID	4557211.
GenomeReviews	Gene locus BAD_0807 in contig AP009256_GR.
KEGG	bad:BAD_0807.
NMPDR	fig|1680.3.peg.1391.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KPGKLPA.
Family and domain databases
HAMAP	MF_00004. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_BIFAA

Accession

Primary (citable) accession number: A1A1K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)