ID   HIS2_BIFAA              Reviewed;          87 AA.
AC   A1A1J2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Phosphoribosyl-ATP pyrophosphatase;
DE            Short=PRA-PH;
DE            EC=3.6.1.31;
GN   Name=hisE; OrderedLocusNames=BAD_0794;
OS   Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083).
OC   Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=367928;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S.,
RA   Hirai S., Tanaka K., Watanabe K.;
RT   "Bifidobacterium adolescentis complete genome sequence.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-
CC       phosphoribosyl)-AMP + diphosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PRA-PH family.
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DR   EMBL; AP009256; BAF39575.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_909657.1; -.
DR   GeneID; 4556154; -.
DR   GenomeReviews; AP009256_GR; BAD_0794.
DR   KEGG; bad:BAD_0794; -.
DR   NMPDR; fig|1680.3.peg.1378; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004636; F:phosphoribosyl-ATP diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01020; -; 1.
DR   InterPro; IPR008179; PRib-ATP_pyrophosphohydrolase.
DR   Pfam; PF01503; PRA-PH; 1.
DR   ProDom; PD002611; Pra_PH/CH; 1.
DR   TIGRFAMs; TIGR03188; histidine_hisI; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Hydrolase; Nucleotide-binding.
FT   CHAIN         1     87       Phosphoribosyl-ATP pyrophosphatase.
FT                                /FTId=PRO_0000319641.
SQ   SEQUENCE   87 AA;  9756 MW;  58400EBCA77E4308 CRC64;
     MKTFESLFAE LSEKAATKQA GSLTVDELAK GTHFIGKKIV EEAGETWIAA EYEGADRTAE
     EMSQLIYHLQ VMMIDRGITL EDIYKNL
//