A1A1I6 (HIS3_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	BAD_0788

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 135	135	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_1000063389

Sequences

	Sequence		Length	Mass (Da)
	A1A1I6 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 494426749E950B48	FASTA	135	15,208
	10 20 30 40 50 60 MTNEAYDNTT TLDPRIAQRL KHDDKGLVAA VIQQFDTKEV LMVGYMNDEA IRRTLTTGRV 70 80 90 100 110 120 TFWSRSRQEY WRKGDTSGHA QYVKSFALDC DGDAILVEVD QVGAACHTGK RSCFEEGGQL 130 PVVVGHRTKE QEGQR

References

[1]

"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009256 Genomic DNA. Translation: BAF39569.1.
RefSeq	YP_909651.1. NC_008618.1.
3D structure databases
ProteinModelPortal	A1A1I6.
SMR	A1A1I6. Positions 19-122.
ModBase	Search...
Protein-protein interaction databases
STRING	A1A1I6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4556177.
GenomeReviews	Gene locus BAD_0788 in contig AP009256_GR.
KEGG	bad:BAD_0788.
NMPDR	fig|1680.3.peg.1372.
PATRIC	21100965. VBIBifAdo27973_0855.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0139.
HOGENOM	HBG294308.
OMA	GACHVGY.
ProtClustDB	PRK00051.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
KO	K01496.
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_BIFAA

Accession

Primary (citable) accession number: A1A1I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program