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A1A1H4 (A1A1H4_BIFAA) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding310 – 3156NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2521Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2751Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2601NADP By similarity
Binding site3281NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2121Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A1A1H4 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 03DDAEDE506DD49D

FASTA40645,208
        10         20         30         40         50         60 
MAKIKVEGKV VELDGDEMTR VIWKDIKNRL ILPYLDVDLD YYDLGIENRD ATDDQVTVDA 

        70         80         90        100        110        120 
AKAIQREHVG VKCATITPDE ARVKEFGLKK MWKSPNGTIR NILGGTIFRE PIVMSNVPRL 

       130        140        150        160        170        180 
VPGWTKPIVV ARHAFGDQYK ATDFKVPGAG TLTVTFTPED GSEPIEHVVY NYGPDGGVAQ 

       190        200        210        220        230        240 
VQYNVNDSIR GFARACFNYG LMRGYPVYLS TKNTILKAYD GQFKDTFAEV FENEYKDKYE 

       250        260        270        280        290        300 
AAGLTYEHRL IDDMVASSLK WHGGYIWACK NYDGDVQSDS VAQGFGSLGL MTSVLMTPDG 

       310        320        330        340        350        360 
QTVEAEAAHG TVTRHYRRWQ KGEKTSTNPI ASIFAWTGGL KHRADLDNTP EVKHFAETLE 

       370        380        390        400 
KVIISTVEGG QMTKDLAMLI GPDQPWLDTE GFMNALDENL AKALAE 

« Hide

References

[1]"Bifidobacterium adolescentis complete genome sequence."
Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009256 Genomic DNA. Translation: BAF39557.1.
RefSeqYP_909639.1. NC_008618.1.

3D structure databases

ProteinModelPortalA1A1H4.
SMRA1A1H4. Positions 1-406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING367928.BAD_0776.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF39557; BAF39557; BAD_0776.
GeneID4556187.
KEGGbad:BAD_0776.
PATRIC21100941. VBIBifAdo27973_0843.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycBADO367928:GHPT-814-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1A1H4_BIFAA
AccessionPrimary (citable) accession number: A1A1H4
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)