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A1A1H4

- A1A1H4_BIFAA

UniProt

A1A1H4 - A1A1H4_BIFAA

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd1

Organism
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei212 – 2121Critical for catalysisUniRule annotation
    Metal bindingi252 – 2521Magnesium or manganeseUniRule annotation
    Binding sitei260 – 2601NADP
    Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation
    Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi310 – 3156NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBADO367928:GHPT-814-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icd1Imported
    Ordered Locus Names:BAD_0776Imported
    OrganismiBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)Imported
    Taxonomic identifieri367928 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000008702: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi367928.BAD_0776.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A1H4.
    SMRiA1A1H4. Positions 1-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiFKDEFQR.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A1H4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVEGKV VELDGDEMTR VIWKDIKNRL ILPYLDVDLD YYDLGIENRD    50
    ATDDQVTVDA AKAIQREHVG VKCATITPDE ARVKEFGLKK MWKSPNGTIR 100
    NILGGTIFRE PIVMSNVPRL VPGWTKPIVV ARHAFGDQYK ATDFKVPGAG 150
    TLTVTFTPED GSEPIEHVVY NYGPDGGVAQ VQYNVNDSIR GFARACFNYG 200
    LMRGYPVYLS TKNTILKAYD GQFKDTFAEV FENEYKDKYE AAGLTYEHRL 250
    IDDMVASSLK WHGGYIWACK NYDGDVQSDS VAQGFGSLGL MTSVLMTPDG 300
    QTVEAEAAHG TVTRHYRRWQ KGEKTSTNPI ASIFAWTGGL KHRADLDNTP 350
    EVKHFAETLE KVIISTVEGG QMTKDLAMLI GPDQPWLDTE GFMNALDENL 400
    AKALAE 406
    Length:406
    Mass (Da):45,208
    Last modified:January 23, 2007 - v1
    Checksum:i03DDAEDE506DD49D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009256 Genomic DNA. Translation: BAF39557.1.
    RefSeqiWP_003809335.1. NC_008618.1.
    YP_909639.1. NC_008618.1.

    Genome annotation databases

    EnsemblBacteriaiBAF39557; BAF39557; BAD_0776.
    GeneIDi4556187.
    KEGGibad:BAD_0776.
    PATRICi21100941. VBIBifAdo27973_0843.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009256 Genomic DNA. Translation: BAF39557.1 .
    RefSeqi WP_003809335.1. NC_008618.1.
    YP_909639.1. NC_008618.1.

    3D structure databases

    ProteinModelPortali A1A1H4.
    SMRi A1A1H4. Positions 1-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 367928.BAD_0776.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF39557 ; BAF39557 ; BAD_0776 .
    GeneIDi 4556187.
    KEGGi bad:BAD_0776.
    PATRICi 21100941. VBIBifAdo27973_0843.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi FKDEFQR.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci BADO367928:GHPT-814-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bifidobacterium adolescentis complete genome sequence."
      Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194aImported.

    Entry informationi

    Entry nameiA1A1H4_BIFAA
    AccessioniPrimary (citable) accession number: A1A1H4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3