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A1A1H4

- A1A1H4_BIFAA

UniProt

A1A1H4 - A1A1H4_BIFAA

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Protein

Isocitrate dehydrogenase [NADP]

Gene
icd1, BAD_0776
Organism
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei212 – 2121Critical for catalysis By similarityUniRule annotation
Metal bindingi252 – 2521Magnesium or manganese By similarityUniRule annotation
Binding sitei260 – 2601NADP By similarityUniRule annotation
Metal bindingi275 – 2751Magnesium or manganese By similarityUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi310 – 3156NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBADO367928:GHPT-814-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icd1Imported
Ordered Locus Names:BAD_0776Imported
OrganismiBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)Imported
Taxonomic identifieri367928 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000008702: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi367928.BAD_0776.

Structurei

3D structure databases

ProteinModelPortaliA1A1H4.
SMRiA1A1H4. Positions 1-406.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiFKDEFQR.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A1H4-1 [UniParc]FASTAAdd to Basket

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MAKIKVEGKV VELDGDEMTR VIWKDIKNRL ILPYLDVDLD YYDLGIENRD    50
ATDDQVTVDA AKAIQREHVG VKCATITPDE ARVKEFGLKK MWKSPNGTIR 100
NILGGTIFRE PIVMSNVPRL VPGWTKPIVV ARHAFGDQYK ATDFKVPGAG 150
TLTVTFTPED GSEPIEHVVY NYGPDGGVAQ VQYNVNDSIR GFARACFNYG 200
LMRGYPVYLS TKNTILKAYD GQFKDTFAEV FENEYKDKYE AAGLTYEHRL 250
IDDMVASSLK WHGGYIWACK NYDGDVQSDS VAQGFGSLGL MTSVLMTPDG 300
QTVEAEAAHG TVTRHYRRWQ KGEKTSTNPI ASIFAWTGGL KHRADLDNTP 350
EVKHFAETLE KVIISTVEGG QMTKDLAMLI GPDQPWLDTE GFMNALDENL 400
AKALAE 406
Length:406
Mass (Da):45,208
Last modified:January 23, 2007 - v1
Checksum:i03DDAEDE506DD49D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009256 Genomic DNA. Translation: BAF39557.1.
RefSeqiWP_003809335.1. NC_008618.1.
YP_909639.1. NC_008618.1.

Genome annotation databases

EnsemblBacteriaiBAF39557; BAF39557; BAD_0776.
GeneIDi4556187.
KEGGibad:BAD_0776.
PATRICi21100941. VBIBifAdo27973_0843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009256 Genomic DNA. Translation: BAF39557.1 .
RefSeqi WP_003809335.1. NC_008618.1.
YP_909639.1. NC_008618.1.

3D structure databases

ProteinModelPortali A1A1H4.
SMRi A1A1H4. Positions 1-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 367928.BAD_0776.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF39557 ; BAF39557 ; BAD_0776 .
GeneIDi 4556187.
KEGGi bad:BAD_0776.
PATRICi 21100941. VBIBifAdo27973_0843.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi FKDEFQR.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci BADO367928:GHPT-814-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bifidobacterium adolescentis complete genome sequence."
    Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Entry informationi

Entry nameiA1A1H4_BIFAA
AccessioniPrimary (citable) accession number: A1A1H4
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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