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A1A1G3 (PYRE_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:BAD_0765
OrganismBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]
Taxonomic identifier367928 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMagnesium
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionorotate phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_1000066209

Regions

Region79 – 8025-phosphoribose 1-diphosphate binding By similarity
Region133 – 14195-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site2715-phosphoribose 1-diphosphate By similarity
Binding site10615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10715-phosphoribose 1-diphosphate By similarity
Binding site11015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site11215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1371Orotate By similarity
Binding site1661Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1A1G3 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 4D0F7CA66530BF7F

FASTA23124,908
        10         20         30         40         50         60 
MTASLDHRFT EFLLESQALK FGEFTLKSGR KSPYFINAGA FNDGRKIARL GAFYAEKIVE 

        70         80         90        100        110        120 
EIEAGNLPKD VDTVFGPAYK GIPLGVSTAI ALTSAHGMEV GYTFDRKEKK DHGDGGMMVG 

       130        140        150        160        170        180 
TQLADGMKVL LVDDVMTAGT AVREVIPKLK AEANVEVIGL VLSVDRMEKT KDSDTSAVKA 

       190        200        210        220        230 
VEAEFGFPVF AIANVKEIFE AGQRIQNADG TPYVTPEIKA AADAYLEQYG A

« Hide

References

[1]"Bifidobacterium adolescentis complete genome sequence."
Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009256 Genomic DNA. Translation: BAF39546.1.
RefSeqYP_909628.1. NC_008618.1.

3D structure databases

ProteinModelPortalA1A1G3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1A1G3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4556608.
GenomeReviewsGene locus BAD_0765 in contig AP009256_GR.
KEGGbad:BAD_0765.
NMPDRfig|1680.3.peg.1347.
PATRIC21100913. VBIBifAdo27973_0831.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMAFAFNRKE.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_BIFAA
AccessionPrimary (citable) accession number: A1A1G3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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