A1A1F9 (A1A1F9_BIFAA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydroorotase EMBL BAF39542.1

Gene names

Name:	pyrC EMBL BAF39542.1
Ordered Locus Names:	BAD_0761

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. SAAS SAAS002195
Cofactor	Binds 2 zinc ions per subunit By similarity. SAAS SAAS002195
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. SAAS SAAS002195
Subunit structure	Homodimer By similarity. SAAS SAAS002195
Sequence similarities	Belongs to the DHOase family. RuleBase RU004949

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS002195
Ligand	Metal-binding SAAS SAAS002195 RuleBase RU004949 Zinc SAAS SAAS002195
Molecular function	Hydrolase SAAS SAAS002195 RuleBase RU004949
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1A1F9 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 11A3E12993705008	FASTA	472	50,920
	10 20 30 40 50 60 MTLTLHDIKV WNTGEVIDLV VPSDTDASVD ASAMTIAPGF EDPHVHFRDP GQTYKESMIS 70 80 90 100 110 120 GCAAAASGGY TNVLIMPNTV PAMDGVKVEA GQPGASEVLD AEYDTVIDYL QHYEAAHGVK 130 140 150 160 170 180 LPVRYDLCVC ASKGRAGHEA TEVADWIGYL PEHGDEHKDA YQLAHPVTAI SDDGSAVTPS 190 200 210 220 230 240 ILEQVFENVK ESGLYLIEHC EHHDTGAVND GPVSRKLGVP GIPEDTELKI VERDIDMSRK 250 260 270 280 290 300 TGVHVHFQHV STAISFDAIR KAKAEGLPIT CETAPHYIAL NDEALLKYGT LAKMNPPLRS 310 320 330 340 350 360 EADRQATIAA VADGTVDLLA TDHAPHTMEE KELGFLDAPN GIIGLECAYG VCHKILVDGG 370 380 390 400 410 420 FISDERLIEL MSTGPAELMG HDKTDITAVL DDYADAVPGD DDTKRVLDLG RVPESDQVDL 430 440 450 460 470 VVLNTGEEWT VDPEKFHSSA RNTPFGGWQV TGRPLATIIG SKLAFSRIDK ED

References

[1]

"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009256 Genomic DNA. Translation: BAF39542.1.
RefSeq	YP_909624.1. NC_008618.1.
3D structure databases
ProteinModelPortal	A1A1F9.
ModBase	Search...
Protein-protein interaction databases
STRING	A1A1F9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4556606.
GenomeReviews	Gene locus BAD_0761 in contig AP009256_GR.
KEGG	bad:BAD_0761.
NMPDR	fig|1680.3.peg.1343.
PATRIC	21100905. VBIBifAdo27973_0827.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0044.
HOGENOM	HBG724623.
OMA	CDVHPVG.
ProtClustDB	CLSK572777.
Family and domain databases
HAMAP	MF_00220_B. PyrC_type2_B. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004722. DHOase. IPR002195. Dihydroorotase_CS. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01465.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1A1F9_BIFAA

Accession

Primary (citable) accession number: A1A1F9

Entry history

Integrated into UniProtKB/TrEMBL:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)