ID   PYRB_BIFAA              Reviewed;         320 AA.
AC   A1A1F7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-MAR-2009, entry version 19.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=BAD_0759;
OS   Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083).
OC   Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=367928;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S.,
RA   Hirai S., Tanaka K., Watanabe K.;
RT   "Bifidobacterium adolescentis complete genome sequence.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; AP009256; BAF39540.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_909622.1; -.
DR   GeneID; 4556605; -.
DR   GenomeReviews; AP009256_GR; BAD_0759.
DR   KEGG; bad:BAD_0759; -.
DR   NMPDR; fig|1680.3.peg.1341; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    320       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000321075.
SQ   SEQUENCE   320 AA;  35386 MW;  F8A289FC738699AD CRC64;
     MVGKSVITLD DLSIRQIQEM LHKAQYIDSH RKEVAHTCEG RVLATLFYEP STRTRLSFET
     AMLRLGGKVI GFAGAQLASV TKGETIADTL KTVSNYVDVV AIRHPKEGAA LVASRAASVP
     VINAGDGGHM HPTQTLADLA TLQSRFGRVT NLTVGLCGDL TFGRTVHSLI ETLCRFGNVN
     FVLISPDELK TPQYVLDRIN ATESCSYTEV KDLVSVIGDL DVLYMTRVQK ERFFNEDDYL
     RLRDTYILDE AKMAYAKKDM AVLHPLPRVN EIAVEVDDDP RAAYFEQVKN GMLMRMALES
     SVVGDELPGY EPLAAKEVEA
//