A1A1F7 (PYRB_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BAD_0759

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.
Sequence caution	The sequence BAF39540.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321075

Sequences

	Sequence		Length	Mass (Da)
	A1A1F7 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: F8A289FC738699AD	FASTA	320	35,386
	10 20 30 40 50 60 MVGKSVITLD DLSIRQIQEM LHKAQYIDSH RKEVAHTCEG RVLATLFYEP STRTRLSFET 70 80 90 100 110 120 AMLRLGGKVI GFAGAQLASV TKGETIADTL KTVSNYVDVV AIRHPKEGAA LVASRAASVP 130 140 150 160 170 180 VINAGDGGHM HPTQTLADLA TLQSRFGRVT NLTVGLCGDL TFGRTVHSLI ETLCRFGNVN 190 200 210 220 230 240 FVLISPDELK TPQYVLDRIN ATESCSYTEV KDLVSVIGDL DVLYMTRVQK ERFFNEDDYL 250 260 270 280 290 300 RLRDTYILDE AKMAYAKKDM AVLHPLPRVN EIAVEVDDDP RAAYFEQVKN GMLMRMALES 310 320 SVVGDELPGY EPLAAKEVEA

References

[1]

"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009256 Genomic DNA. Translation: BAF39540.1. Different initiation.
RefSeq	YP_909622.1. NC_008618.1.
3D structure databases
ProteinModelPortal	A1A1F7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1A1F7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4556605.
GenomeReviews	Gene locus BAD_0759 in contig AP009256_GR.
KEGG	bad:BAD_0759.
NMPDR	fig|1680.3.peg.1341.
PATRIC	21100901. VBIBifAdo27973_0825.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BIFAA

Accession

Primary (citable) accession number: A1A1F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	December 14, 2011
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program