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A1A1A2 (AROC_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:BAD_0704
OrganismBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]
Taxonomic identifier367928 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Chorismate synthase HAMAP MF_00300
PRO_0000322390

Sequences

Sequence LengthMass (Da)Tools
A1A1A2 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 25F264DFBB627E01

FASTA39742,456
        10         20         30         40         50         60 
MLRWQTAGES HGEALVAMIE GLPAGIHVTT EDIVGALARR RLGYGRGARM KFEQDKVRML 

        70         80         90        100        110        120 
TGVRFGETIG SPVAIEIANT EWPKWTEVMS ADPLDHDIPR EGRNAPLSRP RPGHADLTGM 

       130        140        150        160        170        180 
RKYGFDDARP VLERSSARET ASRVALGEVA KQFLEQTLGI RTVSHVLSIG GAGITDPQNA 

       190        200        210        220        230        240 
VLPKPEDLEA LDASPVRTLD KTAEQQMIAR IDEAKENADT LGGVIEVVVY GVPAGIGTYV 

       250        260        270        280        290        300 
ESDRRLDAAL ASAVMGVQAI KGVEIGDGFL EAMRPGSQAH DEMAVGDDGR ITRLSNRAGG 

       310        320        330        340        350        360 
IEGGMSNGQP IVVRAAMKPI PSIPKALRTV DVTTGEAAQA INQRSDNTAV PAAAVVAEAM 

       370        380        390 
VRLTIAQYVL EKFGGDSVAE TKRNAESYVA SWPEHMR

« Hide

References

[1]"Bifidobacterium adolescentis complete genome sequence."
Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009256 Genomic DNA. Translation: BAF39485.1.
RefSeqYP_909567.1. NC_008618.1.

3D structure databases

ProteinModelPortalA1A1A2.
SMRA1A1A2. Positions 1-391.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1A1A2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4557404.
GenomeReviewsGene locus BAD_0704 in contig AP009256_GR.
KEGGbad:BAD_0704.
NMPDRfig|1680.3.peg.1282.
PATRIC21100771. VBIBifAdo27973_0761.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHBG292336.
OMAMLRWLTA.
ProtClustDBPRK05382.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. False negative.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_BIFAA
AccessionPrimary (citable) accession number: A1A1A2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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