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Protein

Chorismate synthase

Gene

aroC

Organism
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.UniRule annotation

Catalytic activityi

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.UniRule annotation

Cofactori

FMNH2UniRule annotationNote: Reduced FMN (FMNH(2)).UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG2)
  2. Bifunctional shikimate kinase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. no protein annotated in this organism
  5. Bifunctional shikimate kinase (aroB)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40NADPUniRule annotation1
Binding sitei46NADPUniRule annotation1
Binding sitei303FMN; via amide nitrogenUniRule annotation1
Binding sitei344FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi134 – 136FMNUniRule annotation3
Nucleotide bindingi258 – 259FMNUniRule annotation2
Nucleotide bindingi318 – 322FMNUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandFAD, Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciBADO367928:G1G2R-762-MONOMER
UniPathwayiUPA00053; UER00090

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate synthaseUniRule annotation (EC:4.2.3.5UniRule annotation)
Short name:
CSUniRule annotation
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyaseUniRule annotation
Gene namesi
Name:aroCUniRule annotation
Ordered Locus Names:BAD_0704
OrganismiBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Taxonomic identifieri367928 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000008702 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003223901 – 397Chorismate synthaseAdd BLAST397

Proteomic databases

PRIDEiA1A1A2

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi367928.BAD_0704

Structurei

3D structure databases

ProteinModelPortaliA1A1A2
SMRiA1A1A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chorismate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D10 Bacteria
COG0082 LUCA
HOGENOMiHOG000060334
KOiK01736
OMAiMLSINAV
OrthoDBiPOG091H00EG

Family and domain databases

CDDicd07304 Chorismate_synthase, 1 hit
Gene3Di3.60.150.10, 1 hit
HAMAPiMF_00300 Chorismate_synth, 1 hit
InterProiView protein in InterPro
IPR000453 Chorismate_synth
IPR035904 Chorismate_synth_AroC_sf
IPR020541 Chorismate_synthase_CS
PANTHERiPTHR21085 PTHR21085, 1 hit
PfamiView protein in Pfam
PF01264 Chorismate_synt, 1 hit
PIRSFiPIRSF001456 Chorismate_synth, 1 hit
SUPFAMiSSF103263 SSF103263, 1 hit
TIGRFAMsiTIGR00033 aroC, 1 hit
PROSITEiView protein in PROSITE
PS00787 CHORISMATE_SYNTHASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

A1A1A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWQTAGES HGEALVAMIE GLPAGIHVTT EDIVGALARR RLGYGRGARM
60 70 80 90 100
KFEQDKVRML TGVRFGETIG SPVAIEIANT EWPKWTEVMS ADPLDHDIPR
110 120 130 140 150
EGRNAPLSRP RPGHADLTGM RKYGFDDARP VLERSSARET ASRVALGEVA
160 170 180 190 200
KQFLEQTLGI RTVSHVLSIG GAGITDPQNA VLPKPEDLEA LDASPVRTLD
210 220 230 240 250
KTAEQQMIAR IDEAKENADT LGGVIEVVVY GVPAGIGTYV ESDRRLDAAL
260 270 280 290 300
ASAVMGVQAI KGVEIGDGFL EAMRPGSQAH DEMAVGDDGR ITRLSNRAGG
310 320 330 340 350
IEGGMSNGQP IVVRAAMKPI PSIPKALRTV DVTTGEAAQA INQRSDNTAV
360 370 380 390
PAAAVVAEAM VRLTIAQYVL EKFGGDSVAE TKRNAESYVA SWPEHMR
Length:397
Mass (Da):42,456
Last modified:January 23, 2007 - v1
Checksum:i25F264DFBB627E01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009256 Genomic DNA Translation: BAF39485.1
RefSeqiWP_011743119.1, NC_008618.1

Genome annotation databases

EnsemblBacteriaiBAF39485; BAF39485; BAD_0704
GeneIDi4557404
KEGGibad:BAD_0704

Similar proteinsi

Entry informationi

Entry nameiAROC_BIFAA
AccessioniPrimary (citable) accession number: A1A1A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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