Reviewed, UniProtKB/Swiss-Prot A1A0R8 (PUR5_BIFAA)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	BAD_0520

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_1000046422

Sequences

	Sequence		Length	Mass (Da)
	A1A0R8-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: E9AC1179D2A4A61D	FASTA	344	35,913
	10 20 30 40 50 60 MPKAYEEAGV SVEAGYEVVK RIKSHVARTN RPGVVGGIGG FGGLFDLASL GYKEPVLISG 70 80 90 100 110 120 TDGVGTKLVV AKMAGKHSTI GIDCVAMCVN DIAAQGAEPL FFLDYIACGK NDPALLEQVV 130 140 150 160 170 180 SGVADGCVQA DCGLIGGETA EMPGMYDEDE YDLAGFAVGV AEKSAIVDGS SIVEGDVLIG 190 200 210 220 230 240 LPSTGVHSNG FSLVRKALFE QAGYTVDTQL DELGGEKLGD VLLTPTKIYV KTLSPLFKAG 250 260 270 280 290 300 VVKGVAHITG GGFIENIPRM IPDGLAAHIN LGSWPVLPIF DVLEKAGEID HMEMFNIFNM 310 320 330 340 GIGMVLAVSA EDADKTMELL KSNGEAGYVL GNIVKKTGED VELQ

References

[1]	"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009256 Genomic DNA. Translation: BAF39301.1.
RefSeq	YP_909383.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1A0R8.
Genome annotation databases
GeneID	4556601.
GenomeReviews	Gene locus BAD_0520 in contig AP009256_GR.
KEGG	bad:BAD_0520.
NMPDR	fig|1680.3.peg.780.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CGKLDPE.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_BIFAA

Accession

Primary (citable) accession number: A1A0R8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)