A0ZZ99 (A0ZZ99_BIFAA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA HAMAP MF_00377

Gene names

Name:	dnaA HAMAP MF_00377 EMBL BAF38782.1
Ordered Locus Names:	BAD_0001

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377 RuleBase RU000577
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family. HAMAP MF_00377 RuleBase RU004227

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00377 RuleBase RU000577
Cellular component	Cytoplasm HAMAP MF_00377
Ligand	ATP-binding HAMAP MF_00377 RuleBase RU000577 DNA-binding HAMAP MF_00377 RuleBase RU000577 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	195 – 202	8	ATP By similarity HAMAP MF_00377

Sequences

	Sequence		Length	Mass (Da)
	A0ZZ99 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: C1B6251F1C6A4307	FASTA	499	56,137
	10 20 30 40 50 60 MADNTTTDPL EQARGVWSDA LALLHQNPSL SVRDKSWLEN VYPEGMWGPT IMLCVPSEAA 70 80 90 100 110 120 QQALQTELNK PLMEALRESA EQDIFPAFKI VEMKPKTEEQ PEETYPRFSP AKSPAKSPAN 130 140 150 160 170 180 ETMQGQLPIP ATMPPEQDHF QSGQNRPLLD PETHLNKNAT FDTFVPGDSN RFARTVALAV 190 200 210 220 230 240 AEGSGHDFNP LCIYGGSGLG KTHLLNAIGN YALVKDPNLK VRYVTSEEFT NEFIEALADT 250 260 270 280 290 300 NQSSGQIKEF NRRYREVDVL LIDDIQFLSG KDATLEQFFH TFNTLHQANK RIVIASDVPP 310 320 330 340 350 360 KDLQGFNERL ISRFESGLTV DVKPPDLETR IAILRMIATM NGSNIPNDVF NLIAERFTEN 370 380 390 400 410 420 IRELEGALNR VTAMASLSNQ PVTKALAEQT LQDFFTTDVE IKPADIITQV AKYFYLTFDD 430 440 450 460 470 480 IVGRSRTKKI ALARQIAMYL VRELTSMSLN DIGLVFGGKD HTTVMHAYTR INDEMQEKQE 490 IYNYVTELTL QLKQRSNDK

References

[1]

"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009256 Genomic DNA. Translation: BAF38782.1.
RefSeq	YP_908864.1. NC_008618.1.
3D structure databases
ProteinModelPortal	A0ZZ99.
ModBase	Search...
Protein-protein interaction databases
STRING	A0ZZ99.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4556250.
GenomeReviews	Gene locus BAD_0001 in contig AP009256_GR.
KEGG	bad:BAD_0001.
NMPDR	fig|1680.3.peg.1456.
PATRIC	21099183. VBIBifAdo27973_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	MHAYTRI.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0ZZ99_BIFAA

Accession

Primary (citable) accession number: A0ZZ99

Entry history

Integrated into UniProtKB/TrEMBL:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)