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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic

Gene

accD

Organism
Gossypium barbadense (Sea-island cotton) (Egyptian cotton)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi232Zinc1
Metal bindingi237Zinc1
Metal bindingi253Zinc1
Metal bindingi256Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri232 – 256C4-typeAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (EC:6.4.1.2)
Short name:
ACCase subunit beta
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta
Gene namesi
Name:accD
Encoded oniPlastid; Chloroplast
OrganismiGossypium barbadense (Sea-island cotton) (Egyptian cotton)
Taxonomic identifieri3634 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMalvalesMalvaceaeMalvoideaeGossypium

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591401 – 497Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticAdd BLAST497

Proteomic databases

PRIDEiA0ZZ44.

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).By similarity

Structurei

3D structure databases

SMRiA0ZZ44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 497CoA carboxyltransferase N-terminalAdd BLAST268

Sequence similaritiesi

Belongs to the AccD/PCCB family.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri232 – 256C4-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A0ZZ44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSWFNLIL SKGELEYRCG LSKSMDSRLG PVENTTVNED PTRNDTDKNI
60 70 80 90 100
HDCSDSSSYY SKVDHLVDVK DIRNFISDDT FLIRDSNQDR YSIYFDSENQ
110 120 130 140 150
IFELNNDHSF LSELESFFYS YHNSSYMNNG SKNDEPHYHF NLYDNDTNCG
160 170 180 190 200
WNNHINSCID SYLRSQICID SSILSGSDNS NDNYISNYIC GEGGNSSEGK
210 220 230 240 250
NFDIITRENG NDLTLKESSN DLDLYKDLWV QCECENCYGV NYKKSLNSKM
260 270 280 290 300
NICEQCGYHL KMRSSDRIEL SIDPGTWGPM DEDMISLDPI EFQSEEELYK
310 320 330 340 350
DRIDFYQRKT GLTEAIQTGT GQLNGIPIAI GVMDFQFMGG SMRSVVGEKI
360 370 380 390 400
TRLIEYATNN FLPLILVCAS GGARMQEGSL SLMQMAKISS ALYDYQSNKK
410 420 430 440 450
LFYVSILTSP TTGGVTASFG MLGDIIIAEP NAYIAFAGKR VIEQTLNKTI
460 470 480 490
PEGSQAAEYL FHKGLFDPIV PRNPLKGVLS ELVQLHGFFP LNQYSIK
Length:497
Mass (Da):56,236
Last modified:January 20, 2009 - v2
Checksum:i9F1DCA05286188FD
GO

Sequence cautioni

The sequence BAF41256 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009123 Genomic DNA. Translation: BAF41256.1. Different initiation.
RefSeqiYP_913196.1. NC_008641.1.

Genome annotation databases

GeneIDi4575183.

Similar proteinsi

Entry informationi

Entry nameiACCD_GOSBA
AccessioniPrimary (citable) accession number: A0ZZ44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: November 22, 2017
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families