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Protein

Beta-lactamase

Gene

blaSHV-72

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS11.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaSHV-72Imported
OrganismiKlebsiella pneumoniaeImported
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1255121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500263177822 – 286Beta-lactamaseSequence analysisAdd BLAST265

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_01607.

Structurei

3D structure databases

ProteinModelPortaliA0ZX81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4108J4B. Bacteria.
COG2367. LUCA.
KOiK18699.

Family and domain databases

InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00146. BETA_LACTAMASE_A. 1 hit.

Sequencei

Sequence statusi: Complete.

A0ZX81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYFRLCIIS LLATLPLAVH ASPQPLEQIK LSESQLSGRV GMIEMDLASG
60 70 80 90 100
RTLTAWRADE RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD
110 120 130 140 150
YSPVSEKHLA DGMTVGELCA AAITMSDNSA ANLLLATVGG PVGLTAFLRQ
160 170 180 190 200
IGDNVTRLDR WETELNEALP GDARDTTTPA SMAATLRKLL TSQRLSARSQ
210 220 230 240 250
RQLLQWMVDD RVAGPLIRSV LPAGWFIADR TGAGERGARG IVALLGPNNK
260 270 280
AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR
Length:286
Mass (Da):31,314
Last modified:February 5, 2008 - v2
Checksum:iF4036E043BAA9022
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM176547 Genomic DNA. Translation: CAJ47127.2.
RefSeqiWP_063864704.1. NG_050107.1.

Genome annotation databases

KEGGiag:CAJ47127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM176547 Genomic DNA. Translation: CAJ47127.2.
RefSeqiWP_063864704.1. NG_050107.1.

3D structure databases

ProteinModelPortaliA0ZX81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_01607.

Chemistry databases

ChEMBLiCHEMBL1255121.

Protein family/group databases

MEROPSiS11.A01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:CAJ47127.

Phylogenomic databases

eggNOGiENOG4108J4B. Bacteria.
COG2367. LUCA.
KOiK18699.

Family and domain databases

InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00146. BETA_LACTAMASE_A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA0ZX81_KLEPN
AccessioniPrimary (citable) accession number: A0ZX81
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: February 5, 2008
Last modified: June 7, 2017
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.