A0ZSX7 (A0ZSX7_CANFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
L type calcium channel alfa1c subunit EMBL BAF41223.1

Gene names

Name:

cacna1c EMBL BAF41223.1

Organism

Canis familiaris (Dog) (Canis lupus familiaris) EMBL BAF41223.1

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	240 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ion channel Voltage-gated channel RuleBase RU003808
Gene Ontology (GO)
Biological_process	adult walking behavior Inferred from electronic annotation. Source: Compara calcium ion-dependent exocytosis Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara growth hormone secretion Inferred from electronic annotation. Source: Compara insulin secretion Inferred from electronic annotation. Source: Compara regulation of blood pressure Inferred from electronic annotation. Source: Compara regulation of organ growth Inferred from electronic annotation. Source: Compara regulation of vasoconstriction Inferred from electronic annotation. Source: Compara smooth muscle contraction involved in micturition Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from electronic annotation. Source: Compara visual learning Inferred from electronic annotation. Source: Compara
Cellular_component	Z disc Inferred from electronic annotation. Source: Compara caveolar macromolecular signaling complex Inferred from electronic annotation. Source: Compara dendritic shaft Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: Compara voltage-gated calcium channel complex Inferred from electronic annotation. Source: Compara
Molecular_function	voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAF41223.1
	Non-terminal residue	240	1	EMBL BAF41223.1

Sequences

	Sequence		Length	Mass (Da)
	A0ZSX7 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 56DA6EDDB849FD17	FASTA	240	27,275
	10 20 30 40 50 60 LVKLLSRGEG IRTLLWTFIK SFQALPYVAL LIVMLFFIYA VIGMQVFGKI ALNDTTEINR 70 80 90 100 110 120 NNNFQTFPQA VLLLFRCATG EAWQDIMLAC MPGKKCAPES EPSNSTEGET PCGSSFAVFY 130 140 150 160 170 180 FISFYMLCAF LIINLFVAVI MDNFDYLTRD WSILGPHHLD EFKRIWAEYD PEAKGRIKHL 190 200 210 220 230 240 DVVTLLRRIQ PPLGFGKLCP HRVACKRLVS MNMPLNSDGT VMFNATLFAL VRTALRIKTE

References

[1]

"Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia." Nishida K., Fujiki A., Sakamoto T., Iwamoto J., Mizumaki K., Hashimoto N., Inoue H. J. Cardiovasc. Electrophysiol. 18:765-772(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Heart EMBL BAF41223.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB262537 mRNA. Translation: BAF41223.1.
UniGene	Cfa.29468.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9615.ENSCAFP00000016146.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231529.
InParanoid	A0ZSX7.
OrthoDB	EOG4RR6GD.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR005451. VDCC_L_a1csu. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF47. PTHR10037:SF47. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR00167. CACHANNEL.
ProtoNet	Search...

Entry information

Entry name

A0ZSX7_CANFA

Accession

Primary (citable) accession number: A0ZSX7

Entry history

Integrated into UniProtKB/TrEMBL:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)