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Protein

Cell cycle control protein 50C

Gene

TMEM30C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle control protein 50C
Alternative name(s):
Transmembrane protein 30C
Gene namesi
Name:TMEM30C
Synonyms:CDC50C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:30443. TMEM30C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Topological domaini56 – 11358ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Cell cycle control protein 50CPRO_0000292845Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA0ZSE6.
PRIDEiA0ZSE6.

Expressioni

Tissue specificityi

Specifically expressed in testis.1 Publication

Gene expression databases

BgeeiA0ZSE6.
CleanExiHS_TMEM30C.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000402698.

Structurei

3D structure databases

ProteinModelPortaliA0ZSE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC50/LEM3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2952. Eukaryota.
COG5035. LUCA.
HOGENOMiHOG000207968.
InParanoidiA0ZSE6.
PhylomeDBiA0ZSE6.

Family and domain databases

InterProiIPR005045. CDC50/LEM3_fam.
IPR030353. TMEM30C.
[Graphical view]
PANTHERiPTHR10926. PTHR10926. 1 hit.
PTHR10926:SF1. PTHR10926:SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0ZSE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERAQHCLS RLLDNSALKQ QELPIHRLYF TARRVLFVFF ATGIFCLCMG
60 70 80 90 100
IILILSARST QEIEINYTRI CANCAKLREN ASNFDKECTC SIPFYLSGKM
110
MVGEIQETRL TLH
Length:113
Mass (Da):13,039
Last modified:June 26, 2007 - v2
Checksum:iE2526360CFFDF5E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129803 Genomic DNA. No translation available.
AB250297 mRNA. Translation: BAF41210.1.
UniGeneiHs.652353.

Genome annotation databases

EnsembliENST00000429523; ENSP00000402698; ENSG00000235156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129803 Genomic DNA. No translation available.
AB250297 mRNA. Translation: BAF41210.1.
UniGeneiHs.652353.

3D structure databases

ProteinModelPortaliA0ZSE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000402698.

Proteomic databases

PaxDbiA0ZSE6.
PRIDEiA0ZSE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429523; ENSP00000402698; ENSG00000235156.

Organism-specific databases

GeneCardsiTMEM30C.
H-InvDBHIX0094381.
HGNCiHGNC:30443. TMEM30C.
MIMi611030. gene.
neXtProtiNX_A0ZSE6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2952. Eukaryota.
COG5035. LUCA.
HOGENOMiHOG000207968.
InParanoidiA0ZSE6.
PhylomeDBiA0ZSE6.

Miscellaneous databases

PROiA0ZSE6.
SOURCEiSearch...

Gene expression databases

BgeeiA0ZSE6.
CleanExiHS_TMEM30C.

Family and domain databases

InterProiIPR005045. CDC50/LEM3_fam.
IPR030353. TMEM30C.
[Graphical view]
PANTHERiPTHR10926. PTHR10926. 1 hit.
PTHR10926:SF1. PTHR10926:SF1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Aberrant termination of reproduction-related TMEM30C transcripts in the hominoids."
    Osada N., Hashimoto K., Hirai M., Kusuda J.
    Gene 392:151-156(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-113, TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico."
    Katoh Y., Katoh M.
    Oncol. Rep. 12:939-943(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCC50C_HUMAN
AccessioniPrimary (citable) accession number: A0ZSE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 11, 2015
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

According to PubMed:17258408, the major transcript has no stop-codon and is probably non protein-coding. A minor transcript is also expressed and encodes the displayed protein which misses C-terminal part compared to other mammalian orthologs.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.