Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0S5V9

- DPP4_ARTOT

UniProt

A0S5V9 - DPP4_ARTOT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dipeptidyl peptidase 4

Gene

DPP4

Organism
Arthroderma otae (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity.1 Publication

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei613 – 6131Charge relay systemPROSITE-ProRule annotation
Active sitei690 – 6901Charge relay systemPROSITE-ProRule annotation
Active sitei725 – 7251Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:DPP4
OrganismiArthroderma otae (Microsporum canis)
Taxonomic identifieri63405 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 775760Dipeptidyl peptidase 4PRO_5000171326Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA0S5V9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0S5V9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFLSLLLLV GVAQAIVPPR EPRPPTGGGK KLLTYKECVP RATLAPRSTS
60 70 80 90 100
LAWINSDEDG QYISQSDDGA LILQNIVTNT NKTLVAADKV PKGFYDYWIK
110 120 130 140 150
PDLTAVLWAT NYTKQYRHSY FANYFILDIE KGSLTPLAED QSGDIQYAQW
160 170 180 190 200
NPVDNSIAYV RGNDLYVWNS GKTKRITENG GPDTFNGVPD WVYEEEIFGD
210 220 230 240 250
RFALWFSPDG EYLAYLRFNE TGVPTYTVPY YKNKQKIAPA YPRELEIRYP
260 270 280 290 300
KVSAKNPTVQ FHLLNLASSE ETSIPVTAFP EDDLIIGEVA WLSSGHDSVA
310 320 330 340 350
FRAFNRVQDT EKIVNVKVGS KESKVIRERD GTDGWIDNLL SMSYIGKVNG
360 370 380 390 400
KEYYVDISDA SGWAHLYLYP VDGGKEIALT KGEWEVTAIL KVDTKSKLIY
410 420 430 440 450
FTSTKFHSTT RHVYSVSYDT KVMTPLVNDR EAAYYSASFS AKGGYYILSY
460 470 480 490 500
QGPNVPYQEL YSVKDKKKPI KTITSNDALI EKLKDYKLPK ITFFEIKLPS
510 520 530 540 550
GESLNVMQRL PPNFNPFKKY PVLFTPYGGP GAQEVSQAWK ALDFKAYITS
560 570 580 590 600
DPELEYVTWT VDNRGTGFKG RKFRSTVTKR LGFLEPQDQV FAAKEILKNR
610 620 630 640 650
WADKDHVGMW GWSYGGFLTA KTMETDSGVF TFGMSTAPVS DFRLYDSMYT
660 670 680 690 700
ERYMKTVELN ADGYSETAVH KTDGFKNLKG HYLIQHGTGD DNVHFQNSAV
710 720 730 740 750
LSNTLMNGGV TPDRLTTQWF TDSDHGVRYD NDSTFQYKQL TKMVYDQKQP
760 770
RPQTTPLHQW SKRVLAALFG EEAEE
Length:775
Mass (Da):87,917
Last modified:January 9, 2007 - v1
Checksum:i311C8FA3E063EA23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ286524 Genomic DNA. Translation: ABB89928.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ286524 Genomic DNA. Translation: ABB89928.1 .

3D structure databases

ProteinModelPortali A0S5V9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.

Entry informationi

Entry nameiDPP4_ARTOT
AccessioniPrimary (citable) accession number: A0S5V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3