A0RZ77 (HIS4_CENSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16

Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	CENSYa_2041

Organism

Cenarchaeum symbiosum (strain A) [Reference proteome] [HAMAP]

Taxonomic identifier

414004 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Thaumarchaeota › Cenarchaeales › Cenarchaeaceae › Cenarchaeum › Cenarchaeum symbiosum

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HisA/HisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014		PRO_0000290571
Sites
	Active site	8	1	Proton acceptor By similarity
	Active site	128	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0RZ77 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 458E4C5BD28CF6EE	FASTA	234	24,969
	10 20 30 40 50 60 MKVIPAIDLM DGQVVRLRRG KAKDKTVYSD DPVKVALTWE KDGADMLHIV DLDATLGRGN 70 80 90 100 110 120 NIDMIRNITD AVSIPVEAAG GLRSIDLVAG ALEGADRVVL GTLAFRDRDA LREILESYGS 130 140 150 160 170 180 KKIVISVDHV KGKIMVDGWR ENTGINLVDA MQGFVGAGFT EFLLTDVDRD GMMQGPETDT 190 200 210 220 230 LGKVCRMSDS HVIASGGITV PGDVKSVRDA GAWGVILGKA LYEGKVSVKG AISC

References

[1]

"Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum." Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y., Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F. Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DP000238 Genomic DNA. Translation: ABK78644.1.
RefSeq	YP_876948.1. NC_014820.1.
3D structure databases
ProteinModelPortal	A0RZ77.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK78644; ABK78644; CENSYa_2041.
GeneID	6372222.
KEGG	csy:CENSYa_2041.
Phylogenomic databases
HOGENOM	HOG000224614.
KO	K01814.
OMA	DGHCVRL.
Enzyme and pathway databases
UniPathway	UPA00031; UER00009.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_01014. HisA.
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. IPR006063. HisA. IPR023016. Isoase_HisA. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00007. TIGR00007. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_CENSY

Accession

Primary (citable) accession number: A0RZ77

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	January 9, 2007
Last modified:	April 3, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program