A0RYV3 (A0RYV3_CENSY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
EC=6.3.5.3 HAMAP MF_00420

Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP MF_00420

Gene names

Name:	purL HAMAP MF_00420
Ordered Locus Names:	CENSYa_1911

Organism

Cenarchaeum symbiosum (strain A)

Taxonomic identifier

414004 [NCBI]

Taxonomic lineage

Archaea › Thaumarchaeota › Cenarchaeales › Cenarchaeaceae › Cenarchaeum

Protein attributes

Sequence length	713 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420
Subunit structure	Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP MF_00420
Subcellular location	Cytoplasm By similarity HAMAP MF_00420.
Sequence similarities	Belongs to the FGAMS family. HAMAP MF_00420

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00420
Cellular component	Cytoplasm HAMAP MF_00420
Ligand	ATP-binding HAMAP MF_00420 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00420 EMBL ABK78520.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0RYV3 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 1C174C7AA0CDE0F9	FASTA	713	74,662
	10 20 30 40 50 60 MSLTGAEARL LREQIGRSPT GTEESIVAAE WSEHCSYKSS RLHLGELPRE GERVIRGSGL 70 80 90 100 110 120 DSGVLDVGDG YVVTVHIESH NHPSAVEPYG GAATGVGGVV RDILSAGTRP VAILDGLRFG 130 140 150 160 170 180 DIASDPHARW LLRGAISGIS DYGNCIGVPT IGGEVGFDPS YKGYAIVDVA AIGFGKRENL 190 200 210 220 230 240 VRNRAAEGDD VVLVGGPTGM DGVGGAQFAS DQLDSDDRSA VQIPDPFMEK LVIEAVLEAA 250 260 270 280 290 300 RAGLIHAMKD LGGGGLACAL SETADSLSVG IEADIGRVHT REGGMRPHEI MVSESQERML 310 320 330 340 350 360 IITPPEKSAR LADICAKFGV PCSVIGSVKS GGALHITHDG TSCAELPAKI VANAKPVERK 370 380 390 400 410 420 SLRPAYLDRI KDDGGVRGPA LLTDTLERLL GSPNIASKER IYGRYDHEVG IRTVLRPGHD 430 440 450 460 470 480 AAVLRLDNGK FLAAKMDGNP GHCYLDPRNG AAGCFEEACR NVACTGATPI GMVDHLQFGS 490 500 510 520 530 540 PEDPGVFWTF LESLHGISEY ARGTGIPCVG GKVSFYNETE RGPIKPTPVI GVFGLAENMP 550 560 570 580 590 600 AAPLAKDGDA LVIIGDTADE MGGSEYLEYI HGFTGGRVPR VDLSASQRNM GVVSSLVGQG 610 620 630 640 650 660 LARAHDCSKG GLGVAVSEMC IQGGTGCRLD LDTMPHKKMP GDRVLFSETH SRYVLAVRGP 670 680 690 700 710 GLPDVLRVLD EKGVPYGTGG FGGESISLSG AGASAELSVD KARGAWRGPL EAI

References

[1]

"Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum." Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y., Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F. Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006) [PubMed: 17114289] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DP000238 Genomic DNA. Translation: ABK78520.1.
3D structure databases
ProteinModelPortal	A0RYV3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HBG311214.
OMA	YGNSFGV.
Family and domain databases
HAMAP	MF_00420. PurL_2. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR010074. PRibForGlyAmidine_synth_II. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 2 hits. PF02769. AIRS_C. 2 hits. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 2 hits. SSF55326. PurM_N-like. 2 hits.
TIGRFAMs	TIGR01736. FGAM_synth_II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0RYV3_CENSY

Accession

Primary (citable) accession number: A0RYV3

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)