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Reviewed, UniProtKB/Swiss-Prot A0RY85 (PYRE_CENSY)

Last modified November 3, 2009. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10
Gene names
Name: pyrE
Ordered Locus Names: CENSYa_1686
OrganismCenarchaeum symbiosum [Complete proteome] [HAMAP]
Taxonomic identifier46770 [NCBI]
Taxonomic lineageArchaea › Thaumarchaeota › Cenarchaeales › Cenarchaeaceae › Cenarchaeum

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Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity.

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000298882

Regions

Region121 – 12995-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9515-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site9915-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1251Orotate By similarity
Binding site1531Orotate By similarity

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Sequences

Sequence LengthMass (Da)Tools
A0RY85-1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: EBDFBDB938B46522

FASTA20020,886
        10         20         30         40         50         60 
MGFVDGFSAF LHSSGAVKFG DFELSGGGRS PYYFDLRSVP SHPHQFRGMI RGLLDSVISE 

        70         80         90        100        110        120 
VGLDRFDTLA SIPTGGLVVA SALAIEAVKP LVYARAAAKG HGTGRTVEGI VRYGARALII 

       130        140        150        160        170        180 
DDVATTGGSV IRAAESLRAA GAIVTDAFVV IDRMEGAEGR LGAEGIKLHR LAGALEVARS 

       190        200 
LHAAGLIPGD VMRQVEGRTR

« Hide

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References

[1]"Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum."
Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y., Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F.
Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006) [PubMed: 17114289] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A.

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Cross-references

Sequence databases

DP000238 Genomic DNA. Translation: ABK78302.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GenomeReviewsGene locus CENSYa_1686 in contig DP000238_GR.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAFDKYLFE.

Enzyme and pathway databases

BRENDA2.4.2.10. 281607.

Family and domain databases

HAMAPMF_01208.
[Tree]
InterProIPR004467. Or_phspho_trans.
IPR002375. Pr/py_Pribosyl_transf_CS.
IPR000836. PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. pyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePYRE_CENSY
AccessionPrimary (citable) accession number: A0RY85
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: January 9, 2007
Last modified: November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents