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A0RXB3

- GSA1_CENSY

UniProt

A0RXB3 - GSA1_CENSY

Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1

Gene

hemL1

Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 2 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSA 1UniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase 1UniRule annotation
    Short name:
    GSA-AT 1UniRule annotation
    Gene namesi
    Name:hemL1UniRule annotation
    Ordered Locus Names:CENSYa_1357
    OrganismiCenarchaeum symbiosum (strain A)
    Taxonomic identifieri414004 [NCBI]
    Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
    ProteomesiUP000000758: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421Glutamate-1-semialdehyde 2,1-aminomutase 1PRO_0000382393Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei258 – 2581N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA0RXB3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000020210.
    KOiK01845.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0RXB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSRGLFERA RKVIPSGVNS PVRYYAPYPF FAASASGGSI RDADGRKYTD    50
    LCNGYGALLL GHGRGEVVRA VSAQLRRGTL FCVPTEQEVE LARLISGNYP 100
    SMESTRLVNT GGEATMTAIR LARGFTKRDR IIKFDGCYHG AHGSVLVKAG 150
    SGSAHLGIST SEGVPRGLAR QTTVIPYNDE AAFEGAAADD VAAVIVEPVM 200
    GNMGVIPPKK GFLRLLRKLS SRLGMQLIFD ETITGFRLSA GGAQEAFGVR 250
    PDITTLAKAL GGGLPIAAVG GKKNIMERLA PGGSVYEAST FAGNPVSVSA 300
    ALASIRTINR IKGRLYPRLE RAAAALASSI ADDAADLGLD RQINRVASIF 350
    QVFFTAEPVT DAASAKRADA ARFDKMFRAL LKNGVFVAPS QFEMASLSAA 400
    HTVEDLRNVS AAYRTALGAA R 421
    Length:421
    Mass (Da):44,446
    Last modified:September 1, 2009 - v2
    Checksum:iBCE8564B16EC352D
    GO

    Sequence cautioni

    The sequence ABK77980.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000238 Genomic DNA. Translation: ABK77980.1. Different initiation.
    RefSeqiYP_876284.1. NC_014820.1.

    Genome annotation databases

    EnsemblBacteriaiABK77980; ABK77980; CENSYa_1357.
    GeneIDi6371537.
    KEGGicsy:CENSYa_1357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000238 Genomic DNA. Translation: ABK77980.1 . Different initiation.
    RefSeqi YP_876284.1. NC_014820.1.

    3D structure databases

    ProteinModelPortali A0RXB3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK77980 ; ABK77980 ; CENSYa_1357 .
    GeneIDi 6371537.
    KEGGi csy:CENSYa_1357.

    Phylogenomic databases

    HOGENOMi HOG000020210.
    KOi K01845.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A.

    Entry informationi

    Entry nameiGSA1_CENSY
    AccessioniPrimary (citable) accession number: A0RXB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3