A0RX41 (A0RX41_CENSY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroxy-acid dehydratase HAMAP MF_00012
Short name=DAD HAMAP MF_00012
EC=4.2.1.9 HAMAP MF_00012

Gene names

Name:	ilvD HAMAP MF_00012
Ordered Locus Names:	CENSYa_1285

Organism

Cenarchaeum symbiosum (strain A)

Taxonomic identifier

414004 [NCBI]

Taxonomic lineage

Archaea › Thaumarchaeota › Cenarchaeales › Cenarchaeaceae › Cenarchaeum

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012
Cofactor	Binds 1 4Fe-4S cluster By similarity. HAMAP MF_00012
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012
Sequence similarities	Belongs to the IlvD/Edd family. HAMAP MF_00012

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis HAMAP MF_00012
Ligand	4Fe-4S HAMAP MF_00012 Iron Iron-sulfur Metal-binding
Molecular function	Lyase HAMAP MF_00012 EMBL ABK77908.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW dihydroxy-acid dehydratase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	102	1	Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012
	Metal binding	174	1	Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012

Sequences

	Sequence		Length	Mass (Da)
	A0RX41 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 6FCB110FB6582F58	FASTA	538	56,034
	10 20 30 40 50 60 MYKAMGLDDA DLGKQFVGVC HTGNESTPCN IHLPGLALQA KEGVSAGGAT PREFSTIAVS 70 80 90 100 110 120 DGIAMGHEGM KSSLVSREVI ADSIELMVRA HQYDALVGIA GCDKSLPGTM MAMARLNVPS 130 140 150 160 170 180 VFVYGGSIMP GMLDGRELTV VDVYEAVGSY DAGKISIDDL KNIENTACPS AGSCGGMFTA 190 200 210 220 230 240 NTMASISEAI GLALPGSASP PAEDDRRAAV ARDSGAACAR LLELGIRPSD ILTFEAFENA 250 260 270 280 290 300 ITVLNALGGS TNGVLHLLAL AGEAGIGLTY DDFERVRKRT PHLADMKPGG SYVMNSLDKA 310 320 330 340 350 360 GGIPLVLRKL DGQGLLNGSC LTVSGKTIHE DLAGAPPEPS QKIVRPVENP MHAEGTAVIL 370 380 390 400 410 420 RGSLAPDGAV IKTAGVEMTR FEGNARTFDR EEDAFGAVSR GEISEGDVLV IRYEGPRGGP 430 440 450 460 470 480 GMREMLSTTA ALVGQGLGKK VAMVTDGRFS GGTRGFMVGH VAPEAFVGGP IALVKDGDRI 490 500 510 520 530 TVDTEKNSID LLVSAEELDK RRELWTRPEP NYTTGALAKY ASLVGSAAQG ARTMPAQV

References

[1]

"Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum." Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y., Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F. Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006) [PubMed: 17114289] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DP000238 Genomic DNA. Translation: ABK77908.1.
3D structure databases
ProteinModelPortal	A0RX41.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HBG671001.
OMA	NMPGAMI.
Family and domain databases
HAMAP	MF_00012. IlvD. [Tree]
InterPro	IPR015928. Aconitase/3IPM_dehydase_swvl. IPR004404. DihydroxyA_deHydtase. IPR000581. DiOHA_6PGluconate_deHydtase. IPR020558. DiOHA_6PGluconate_deHydtase_CS. [Graphical view]
PANTHER	PTHR21000. ILVD_EDD_family. 1 hit.
Pfam	PF00920. ILVD_EDD. 1 hit. [Graphical view]
SUPFAM	SSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMs	TIGR00110. IlvD. 1 hit.
PROSITE	PS00886. ILVD_EDD_1. 1 hit. PS00887. ILVD_EDD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0RX41_CENSY

Accession

Primary (citable) accession number: A0RX41

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)