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A0RWW0 (ARGC_CENSY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase

Short name=AGPR
EC=1.2.1.-
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde/N-acetyl-aminoadipate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Name:argC
Synonyms:lysY
Ordered Locus Names:CENSYa_1203
OrganismCenarchaeum symbiosum (strain A)
Taxonomic identifier414004 [NCBI]
Taxonomic lineageArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP MF_00150

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150

N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH. HAMAP MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5. HAMAP MF_00150

Subcellular location

Cytoplasm Probable HAMAP MF_00150.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase HAMAP MF_00150
PRO_1000010987

Sites

Active site1491 By similarity

Sequences

Sequence LengthMass (Da)Tools
A0RWW0 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 62FB3BA2351B940E

FASTA34838,320
        10         20         30         40         50         60 
MKVGVVGASG YVGGETLRLL VNHPDVEIAA VTSRQHVGEY LHRVQPSLRG FTDLTFSELD 

        70         80         90        100        110        120 
YDRLSDSCDL VFTAVPHGTA TDIVRALYDR DIKVIDLSAD YRLHDPADYT KWYGWEHPHP 

       130        140        150        160        170        180 
DYLSKSVFGI PELHREEIRS AKLVSCPGCM AVTSILALAP PVREGLVDTE HIVVDSKIGS 

       190        200        210        220        230        240 
SGAGAGAGTA HAMRAGVIRP YKPAKHRHTG EIEQELSGIA GKKIRVSMSP HAVDVVRGIL 

       250        260        270        280        290        300 
CTNHVFLTRE ASEKDLWKMY RQAYGEERFV RLIRDKKGLY KFPDPKFLVG SNFCDIGFDL 

       310        320        330        340 
DEDNNRLVAI SASDNLMKGA AGSAIQNMNI MAGLDEMSGL RYTPLTPV 

« Hide

References

[1]"Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum."
Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y., Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F.
Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006) [PubMed: 17114289] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DP000238 Genomic DNA. Translation: ABK77827.1.

3D structure databases

ProteinModelPortalA0RWW0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHBG294213.
OMAVYRYPEP.

Family and domain databases

HAMAPMF_00150. ArgC_type1.
[Tree]
InterProIPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. ArgC. 1 hit.
PROSITEPS01224. ARGC. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_CENSY
AccessionPrimary (citable) accession number: A0RWW0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families