Reviewed, UniProtKB/Swiss-Prot A0RWW0 (ARGC_CENSY)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
    EC=1.2.1.-
Alternative name(s):
    N-acetyl-glutamate semialdehyde/N-acetyl-aminoadipate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Synonyms:	lysY
Ordered Locus Names:	CENSYa_1203

Organism

Cenarchaeum symbiosum [Complete proteome] [HAMAP]

Taxonomic identifier

46770 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Cenarchaeales › Cenarchaeaceae › Cenarchaeum

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in both the arginine and lysine biosynthetic pathways By similarity.
Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150 N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150 Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase HAMAP MF_00150		PRO_1000010987
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0RWW0-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 62FB3BA2351B940E	FASTA	348	38,320
	10 20 30 40 50 60 MKVGVVGASG YVGGETLRLL VNHPDVEIAA VTSRQHVGEY LHRVQPSLRG FTDLTFSELD 70 80 90 100 110 120 YDRLSDSCDL VFTAVPHGTA TDIVRALYDR DIKVIDLSAD YRLHDPADYT KWYGWEHPHP 130 140 150 160 170 180 DYLSKSVFGI PELHREEIRS AKLVSCPGCM AVTSILALAP PVREGLVDTE HIVVDSKIGS 190 200 210 220 230 240 SGAGAGAGTA HAMRAGVIRP YKPAKHRHTG EIEQELSGIA GKKIRVSMSP HAVDVVRGIL 250 260 270 280 290 300 CTNHVFLTRE ASEKDLWKMY RQAYGEERFV RLIRDKKGLY KFPDPKFLVG SNFCDIGFDL 310 320 330 340 DEDNNRLVAI SASDNLMKGA AGSAIQNMNI MAGLDEMSGL RYTPLTPV

References

[1]

"Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum." Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y., Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F. Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006) [PubMed: 17114289] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DP000238 Genomic DNA. Translation: ABK77827.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus CENSYa_1203 in contig DP000238_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A0RWW0. GCNATAT.
Enzyme and pathway databases
BRENDA	1.2.1.38. 281607.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_CENSY

Accession

Primary (citable) accession number: A0RWW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)