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A0RWD6

- DNLI_CENSY

UniProt

A0RWD6 - DNLI_CENSY

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Protein
DNA ligase
Gene
lig, CENSYa_1021
Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATP By similarity
Active sitei252 – 2521N6-AMP-lysine intermediate By similarity
Binding sitei257 – 2571ATP By similarity
Binding sitei272 – 2721ATP By similarity
Binding sitei302 – 3021ATP By similarity
Binding sitei342 – 3421ATP By similarity
Binding sitei417 – 4171ATP By similarity
Binding sitei423 – 4231ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:CENSYa_1021
OrganismiCenarchaeum symbiosum (strain A)
Taxonomic identifieri414004 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
ProteomesiUP000000758: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589DNA ligaseUniRule annotation
PRO_0000365244Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0RWD6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RWD6-1 [UniParc]FASTAAdd to Basket

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MQFSVLAGSL EKMESTAKRL ELTGILEELL RETPHEVIAQ IVYLIQGKLR    50
PEFEGIELGV AEKLAVRAVS KSSGMPAARI EAAYRRDGDL GRAASSILEQ 100
KTQTTFLAEE ITVERVYDTL MRIARLEGAR SQDMKMRHIS SLLNDASPRD 150
ACYILKLILG TLRLGIAENT VMDALAAAFT GSKSNRPELE RAYNVSSDLG 200
RVAEAVSSGG LEAVRGFAVA VFSPIRPMLA DRVRSESEAL EKMGAGLAAE 250
YKLDGERVQV HLSGGRVELF SRSLENITAY YPDIVERIPG RLRAREAVLE 300
AEAVAVNEET GEFLPFQELM HRRRKYDIDK AVMRYPITVN FFDILYLDGR 350
DCLGISYSER RALLEGVVDE DSFARCVPVS TIPDESALED SLENSINAGC 400
EGLMLKLPDA PYRAGSRGGY WLKLKREYRN ELGDSLDLVI IGAFFGKGRR 450
TGRYGTLLLA TYDDSRDTFP SICKVGTGFT DEDLDQLYQL LSPRVTLKRN 500
PRIDSGMEAD VWFDPEVVME VVASEITLSP VHKTALDSVR KGAGLALRFP 550
KFTGKLRTEK TAEDASTDQE VIALYKSQKK VVPDGQPGV 589
Length:589
Mass (Da):65,183
Last modified:March 3, 2009 - v2
Checksum:i862D43048CA15D39
GO

Sequence cautioni

The sequence ABK77653.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000238 Genomic DNA. Translation: ABK77653.1. Different initiation.
RefSeqiYP_875957.1. NC_014820.1.

Genome annotation databases

EnsemblBacteriaiABK77653; ABK77653; CENSYa_1021.
GeneIDi6371201.
KEGGicsy:CENSYa_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000238 Genomic DNA. Translation: ABK77653.1 . Different initiation.
RefSeqi YP_875957.1. NC_014820.1.

3D structure databases

ProteinModelPortali A0RWD6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK77653 ; ABK77653 ; CENSYa_1021 .
GeneIDi 6371201.
KEGGi csy:CENSYa_1021.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A.

Entry informationi

Entry nameiDNLI_CENSY
AccessioniPrimary (citable) accession number: A0RWD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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