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A0RWD6

- DNLI_CENSY

UniProt

A0RWD6 - DNLI_CENSY

Protein

DNA ligase

Gene

lig

Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei250 – 2501ATPUniRule annotation
    Active sitei252 – 2521N6-AMP-lysine intermediateUniRule annotation
    Binding sitei257 – 2571ATPUniRule annotation
    Binding sitei272 – 2721ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei342 – 3421ATPUniRule annotation
    Binding sitei417 – 4171ATPUniRule annotation
    Binding sitei423 – 4231ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:CENSYa_1021
    OrganismiCenarchaeum symbiosum (strain A)
    Taxonomic identifieri414004 [NCBI]
    Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
    ProteomesiUP000000758: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 589589DNA ligasePRO_0000365244Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA0RWD6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0RWD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFSVLAGSL EKMESTAKRL ELTGILEELL RETPHEVIAQ IVYLIQGKLR    50
    PEFEGIELGV AEKLAVRAVS KSSGMPAARI EAAYRRDGDL GRAASSILEQ 100
    KTQTTFLAEE ITVERVYDTL MRIARLEGAR SQDMKMRHIS SLLNDASPRD 150
    ACYILKLILG TLRLGIAENT VMDALAAAFT GSKSNRPELE RAYNVSSDLG 200
    RVAEAVSSGG LEAVRGFAVA VFSPIRPMLA DRVRSESEAL EKMGAGLAAE 250
    YKLDGERVQV HLSGGRVELF SRSLENITAY YPDIVERIPG RLRAREAVLE 300
    AEAVAVNEET GEFLPFQELM HRRRKYDIDK AVMRYPITVN FFDILYLDGR 350
    DCLGISYSER RALLEGVVDE DSFARCVPVS TIPDESALED SLENSINAGC 400
    EGLMLKLPDA PYRAGSRGGY WLKLKREYRN ELGDSLDLVI IGAFFGKGRR 450
    TGRYGTLLLA TYDDSRDTFP SICKVGTGFT DEDLDQLYQL LSPRVTLKRN 500
    PRIDSGMEAD VWFDPEVVME VVASEITLSP VHKTALDSVR KGAGLALRFP 550
    KFTGKLRTEK TAEDASTDQE VIALYKSQKK VVPDGQPGV 589
    Length:589
    Mass (Da):65,183
    Last modified:March 3, 2009 - v2
    Checksum:i862D43048CA15D39
    GO

    Sequence cautioni

    The sequence ABK77653.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000238 Genomic DNA. Translation: ABK77653.1. Different initiation.
    RefSeqiYP_875957.1. NC_014820.1.

    Genome annotation databases

    EnsemblBacteriaiABK77653; ABK77653; CENSYa_1021.
    GeneIDi6371201.
    KEGGicsy:CENSYa_1021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000238 Genomic DNA. Translation: ABK77653.1 . Different initiation.
    RefSeqi YP_875957.1. NC_014820.1.

    3D structure databases

    ProteinModelPortali A0RWD6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK77653 ; ABK77653 ; CENSYa_1021 .
    GeneIDi 6371201.
    KEGGi csy:CENSYa_1021.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A.

    Entry informationi

    Entry nameiDNLI_CENSY
    AccessioniPrimary (citable) accession number: A0RWD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3