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A0RWD6 (DNLI_CENSY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:CENSYa_1021
OrganismCenarchaeum symbiosum (strain A) [Reference proteome] [HAMAP]
Taxonomic identifier414004 [NCBI]
Taxonomic lineageArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence caution

The sequence ABK77653.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589DNA ligase HAMAP-Rule MF_00407
PRO_0000365244

Sites

Active site2521N6-AMP-lysine intermediate By similarity
Binding site2501ATP By similarity
Binding site2571ATP By similarity
Binding site2721ATP By similarity
Binding site3021ATP By similarity
Binding site3421ATP By similarity
Binding site4171ATP By similarity
Binding site4231ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0RWD6 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: 862D43048CA15D39

FASTA58965,183
        10         20         30         40         50         60 
MQFSVLAGSL EKMESTAKRL ELTGILEELL RETPHEVIAQ IVYLIQGKLR PEFEGIELGV 

        70         80         90        100        110        120 
AEKLAVRAVS KSSGMPAARI EAAYRRDGDL GRAASSILEQ KTQTTFLAEE ITVERVYDTL 

       130        140        150        160        170        180 
MRIARLEGAR SQDMKMRHIS SLLNDASPRD ACYILKLILG TLRLGIAENT VMDALAAAFT 

       190        200        210        220        230        240 
GSKSNRPELE RAYNVSSDLG RVAEAVSSGG LEAVRGFAVA VFSPIRPMLA DRVRSESEAL 

       250        260        270        280        290        300 
EKMGAGLAAE YKLDGERVQV HLSGGRVELF SRSLENITAY YPDIVERIPG RLRAREAVLE 

       310        320        330        340        350        360 
AEAVAVNEET GEFLPFQELM HRRRKYDIDK AVMRYPITVN FFDILYLDGR DCLGISYSER 

       370        380        390        400        410        420 
RALLEGVVDE DSFARCVPVS TIPDESALED SLENSINAGC EGLMLKLPDA PYRAGSRGGY 

       430        440        450        460        470        480 
WLKLKREYRN ELGDSLDLVI IGAFFGKGRR TGRYGTLLLA TYDDSRDTFP SICKVGTGFT 

       490        500        510        520        530        540 
DEDLDQLYQL LSPRVTLKRN PRIDSGMEAD VWFDPEVVME VVASEITLSP VHKTALDSVR 

       550        560        570        580 
KGAGLALRFP KFTGKLRTEK TAEDASTDQE VIALYKSQKK VVPDGQPGV 

« Hide

References

[1]"Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum."
Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y., Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F.
Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DP000238 Genomic DNA. Translation: ABK77653.1. Different initiation.
RefSeqYP_875957.1. NC_014820.1.

3D structure databases

ProteinModelPortalA0RWD6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK77653; ABK77653; CENSYa_1021.
GeneID6371201.
KEGGcsy:CENSYa_1021.

Phylogenomic databases

HOGENOMHOG000036008.
KOK10747.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_CENSY
AccessionPrimary (citable) accession number: A0RWD6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families