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A0RVQ7

- MTAP_CENSY

UniProt

A0RVQ7 - MTAP_CENSY

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
mtnP, CENSYa_0791
Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei145 – 1451Important for substrate specificity By similarity
Binding sitei163 – 1631Substrate; via amide nitrogen By similarity
Binding sitei164 – 1641Phosphate By similarity
Sitei198 – 1981Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Gene namesi
Name:mtnP
Ordered Locus Names:CENSYa_0791
OrganismiCenarchaeum symbiosum (strain A)
Taxonomic identifieri414004 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
ProteomesiUP000000758: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000415103Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0RVQ7.
SMRiA0RVQ7. Positions 2-238.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni36 – 372Phosphate binding By similarity
Regioni69 – 702Phosphate binding By similarity
Regioni187 – 1893Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228987.
KOiK00772.
OMAiDYTFYNG.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RVQ7-1 [UniParc]FASTAAdd to Basket

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MLDNAEELSM DTPYGAPSDT ITLGGIGGRR LAFIPRHGKK HNIAPHKINY    50
RANIWALQKL GVSRVVAPSA VGSLREELAP GRFVVPSQFL DFTRTREGSF 100
SEDGRVIHIS VAEPFCPELR TVLLDAAGDA HDGGTYACIE GPRFSTRAES 150
ALFRAAGADI IGMTMVPECQ LSREAQMCYA SVSTVTDYDA WAEKAVTAKE 200
VLATLADNVE RTKALLAKLI PTIPRDRKCT CADALAEAEF 240
Length:240
Mass (Da):25,982
Last modified:January 9, 2007 - v1
Checksum:iE9CEEEFD720F522A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000238 Genomic DNA. Translation: ABK77424.1.
RefSeqiYP_875728.1. NC_014820.1.

Genome annotation databases

EnsemblBacteriaiABK77424; ABK77424; CENSYa_0791.
GeneIDi6370971.
KEGGicsy:CENSYa_0791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000238 Genomic DNA. Translation: ABK77424.1 .
RefSeqi YP_875728.1. NC_014820.1.

3D structure databases

ProteinModelPortali A0RVQ7.
SMRi A0RVQ7. Positions 2-238.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK77424 ; ABK77424 ; CENSYa_0791 .
GeneIDi 6370971.
KEGGi csy:CENSYa_0791.

Phylogenomic databases

HOGENOMi HOG000228987.
KOi K00772.
OMAi DYTFYNG.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A.

Entry informationi

Entry nameiMTAP_CENSY
AccessioniPrimary (citable) accession number: A0RVQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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