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A0RVQ7

- MTAP_CENSY

UniProt

A0RVQ7 - MTAP_CENSY

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei145 – 1451Important for substrate specificityUniRule annotation
Binding sitei163 – 1631Substrate; via amide nitrogenUniRule annotation
Binding sitei164 – 1641PhosphateUniRule annotation
Sitei198 – 1981Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:CENSYa_0791
OrganismiCenarchaeum symbiosum (strain A)
Taxonomic identifieri414004 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
ProteomesiUP000000758: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240S-methyl-5'-thioadenosine phosphorylasePRO_0000415103Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0RVQ7.
SMRiA0RVQ7. Positions 2-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni36 – 372Phosphate bindingUniRule annotation
Regioni69 – 702Phosphate bindingUniRule annotation
Regioni187 – 1893Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228987.
KOiK00772.
OMAiDYTFYNG.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RVQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDNAEELSM DTPYGAPSDT ITLGGIGGRR LAFIPRHGKK HNIAPHKINY
60 70 80 90 100
RANIWALQKL GVSRVVAPSA VGSLREELAP GRFVVPSQFL DFTRTREGSF
110 120 130 140 150
SEDGRVIHIS VAEPFCPELR TVLLDAAGDA HDGGTYACIE GPRFSTRAES
160 170 180 190 200
ALFRAAGADI IGMTMVPECQ LSREAQMCYA SVSTVTDYDA WAEKAVTAKE
210 220 230 240
VLATLADNVE RTKALLAKLI PTIPRDRKCT CADALAEAEF
Length:240
Mass (Da):25,982
Last modified:January 9, 2007 - v1
Checksum:iE9CEEEFD720F522A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000238 Genomic DNA. Translation: ABK77424.1.
RefSeqiYP_875728.1. NC_014820.1.

Genome annotation databases

EnsemblBacteriaiABK77424; ABK77424; CENSYa_0791.
GeneIDi6370971.
KEGGicsy:CENSYa_0791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000238 Genomic DNA. Translation: ABK77424.1 .
RefSeqi YP_875728.1. NC_014820.1.

3D structure databases

ProteinModelPortali A0RVQ7.
SMRi A0RVQ7. Positions 2-238.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK77424 ; ABK77424 ; CENSYa_0791 .
GeneIDi 6370971.
KEGGi csy:CENSYa_0791.

Phylogenomic databases

HOGENOMi HOG000228987.
KOi K00772.
OMAi DYTFYNG.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A.

Entry informationi

Entry nameiMTAP_CENSY
AccessioniPrimary (citable) accession number: A0RVQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3