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Protein

Riboflavin kinase

Gene

ribK

Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).By similarity

Catalytic activityi

CTP + riboflavin = CDP + FMN.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (CTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin kinase (ribK)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (CTP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98MagnesiumBy similarity1
Metal bindingi100MagnesiumBy similarity1
Binding sitei156FMNBy similarity1
Binding sitei164FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 74CDPBy similarity6
Nucleotide bindingi169 – 172CDPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandFlavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00276; UER00929.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinase (EC:2.7.1.161)
Short name:
RFK
Alternative name(s):
CTP-dependent riboflavin kinase
CTP:riboflavin 5'-phosphotransferase
Flavokinase
Gene namesi
Name:ribK
Ordered Locus Names:CENSYa_0128
OrganismiCenarchaeum symbiosum (strain A)
Taxonomic identifieri414004 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
Proteomesi
  • UP000000758 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003220831 – 193Riboflavin kinaseAdd BLAST193

Structurei

3D structure databases

ProteinModelPortaliA0RTV6.
SMRiA0RTV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 59H-T-H motif-likeAdd BLAST59
Regioni60 – 193Riboflavin kinaseAdd BLAST134

Sequence similaritiesi

Belongs to the archaeal riboflavin kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000015512.
KOiK07732.
OMAiFTPYPGT.

Family and domain databases

CDDicd00090. HTH_ARSR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
2.40.30.30. 1 hit.
HAMAPiMF_01285. Riboflavin_kinase. 1 hit.
InterProiView protein in InterPro
IPR011991. ArsR-like_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR023470. Riboflavin_kinase_archaeal.
IPR023602. Riboflavin_kinase_CTP-dep.
IPR023465. Riboflavin_kinase_dom_sf.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF01982. CTP-dep_RFKase. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF82114. SSF82114. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0RTV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISQQAASQ HLRELEDEGL ITRNAEGKGI SVMVTDKGRH ELLRVYNILH
60 70 80 90 100
DSLHSRPDHV EITGTLVSGM NEGAYYMSRE GYTGQFQERL GYVPFPGTLN
110 120 130 140 150
VDTDRKHGPE IARLDGMNGT IIDGFTDGKR SYGWVKCFAG TLNGTIPCHL
160 170 180 190
IRLERTHHGS STVELISKLD IRKETGLDDG GKITIRIPLE QED
Length:193
Mass (Da):21,446
Last modified:January 9, 2007 - v1
Checksum:iC390EBC862001E2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000238 Genomic DNA. Translation: ABK76773.1.

Genome annotation databases

EnsemblBacteriaiABK76773; ABK76773; CENSYa_0128.
KEGGicsy:CENSYa_0128.
PATRICifig|414004.10.peg.117.

Similar proteinsi

Entry informationi

Entry nameiRIFK_CENSY
AccessioniPrimary (citable) accession number: A0RTV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: January 31, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families