Reviewed, UniProtKB/Swiss-Prot A0RR75 (RIBA_CAMFF)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase-2
    EC=3.5.4.25
Alternative name(s):
    GTP cyclohydrolase II

Gene names

Name:	ribA
Ordered Locus Names:	CFF8240_1575

Organism

Campylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]

Taxonomic identifier

360106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate By similarity.
Catalytic activity	GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. HAMAP MF_00179
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; 6,7-dimethyl-8-(1-D-ribityl)lumazine from GTP: step 1/4. HAMAP MF_00179
Sequence similarities	Belongs to the GTP cyclohydrolase II family.

Ontologies

Keywords
Biological process	Riboflavin biosynthesis
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase II activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	GTP cyclohydrolase-2 HAMAP MF_00179		PRO_1000040557
Regions
	Nucleotide binding	48 – 52	5	GTP By similarity
	Nucleotide binding	90 – 92	3	GTP By similarity
Sites
	Active site	124	1	Proton acceptor Potential
	Active site	126	1	Nucleophile By similarity
	Metal binding	53	1	Zinc; catalytic By similarity
	Metal binding	64	1	Zinc; catalytic By similarity
	Metal binding	66	1	Zinc; catalytic By similarity
	Binding site	69	1	GTP By similarity
	Binding site	112	1	GTP By similarity
	Binding site	147	1	GTP By similarity
	Binding site	152	1	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0RR75-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 57B11CC0AB21A647	FASTA	195	22,228
	10 20 30 40 50 60 MEIIKSNIAN LPSRFGKFQI KSYKEGCCKE HLTIFSPNLD VTKTVNVRIH SECLTGDAIG 70 80 90 100 110 120 SLKCDCRDQL EASLKYINKH GGMVIYLRQE GRNIGLLNKV NAYALQDNGL DTIEANHQLG 130 140 150 160 170 180 FKADERTYEI VDFILKDFGI KSINLLTNNP LKLASLTCVN IEKRIPIEIE SNEFNKDYLK 190 VKKEQMGHML DEFTR

References

[1]	"Sequence of Campylobacter fetus subsp. fetus 82-40." Fouts D.E., Nelson K.E. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000487 Genomic DNA. Translation: ABK81791.1.
RefSeq	YP_892708.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4538031.
GenomeReviews	Gene locus CFF8240_1575 in contig CP000487_GR.
KEGG	cff:CFF8240_1575.
NMPDR	fig|360106.5.peg.1507.
TIGR	CFF8240_1575.
Phylogenomic databases
OMA	A0RR75. YEIVEFI.
Family and domain databases
HAMAP	MF_00179. [Tree]
InterPro	IPR000926. GTP_CycHdrlase_II. [Graphical view]
Pfam	PF00925. GTP_cyclohydro2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00505. ribA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIBA_CAMFF

Accession

Primary (citable) accession number: A0RR75

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)