A0RR73 (OTC_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	CFF8240_1573

Organism

Campylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]

Taxonomic identifier

360106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000065082
Regions
	Region	51 – 55	5	Carbamoyl phosphate binding By similarity
	Region	263 – 266	4	Ornithine binding By similarity
Sites
	Binding site	102	1	Carbamoyl phosphate By similarity
	Binding site	129	1	Carbamoyl phosphate By similarity
	Site	26	1	Important for structural integrity By similarity
	Site	142	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0RR73 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 1D2B8C894E1F7E1F	FASTA	309	34,646
	10 20 30 40 50 60 MRHFLTLNDL DKNEILDILS LAKDIKKEAK SRNYISYLKD QTLAMIFEKS STRTRVSFEV 70 80 90 100 110 120 GIHQLGGKGL FLSSRDIQLG RGEPVKDTAR VLGRMVDMIM ARVYKQSDLE ELAKFSGVPV 130 140 150 160 170 180 INGLSDDFHP VQLMSDLLTL SELGLNLQTM KVAYVGDGNN MTNSWLMAAS KLGFELRVAT 190 200 210 220 230 240 PKGYEVPQWV LDIAKQNSKI SCANLIITDN PKAAISGADV VTTDTWVSMG QEDEKEKRIN 250 260 270 280 290 300 DFAGYCVDDD MMSLAAKDAK FLHCLPAYRG YEVSEAVFEA HAGEIFSEAE NRLHAQKAVM VWCDRKRYE

References

[1]	"Sequence of Campylobacter fetus subsp. fetus 82-40." Fouts D.E., Nelson K.E. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 82-40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000487 Genomic DNA. Translation: ABK81844.1.
RefSeq	YP_892706.1. NC_008599.1.
3D structure databases
ProteinModelPortal	A0RR73.
ModBase	Search...
Protein-protein interaction databases
STRING	A0RR73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4538515.
GenomeReviews	Gene locus CFF8240_1573 in contig CP000487_GR.
KEGG	cff:CFF8240_1573.
NMPDR	fig|360106.5.peg.1505.
PATRIC	20037664. VBICamFet25865_1533.
TIGR	CFF8240_1573.
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	GVDCVVT.
Enzyme and pathway databases
BioCyc	CFET360106:CFF8240_1573-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_CAMFF

Accession

Primary (citable) accession number: A0RR73

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program