A0RQV9 (DCUP_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	CFF8240_1456

Organism

Campylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]

Taxonomic identifier

360106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000023889
Regions
	Region	21 – 25	5	Substrate binding By similarity
Sites
	Binding site	71	1	Substrate By similarity
	Binding site	148	1	Substrate By similarity
	Binding site	203	1	Substrate By similarity
	Binding site	316	1	Substrate By similarity
	Site	71	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0RQV9 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: FC200B1B120F9490	FASTA	343	38,582
	10 20 30 40 50 60 MIFIDACFGK PTPYTPIWMM RQAGRYLPEY MAVRDAAGDF LSLCKDYKKA SEVTLQPVDI 70 80 90 100 110 120 LGVDAAIMFS DILVVPLEMG MELKFIKGEG PVFENPILSM DSLDKLSVEK AVKNLSYVYD 130 140 150 160 170 180 TIKLTREKLS SDKALIGFCG APWTIATYMI EGGSTKTYNI SKKMLYDNPQ FLHAILRKVT 190 200 210 220 230 240 NALKLYLEEQ IKAGVNAVQI FDSWASALEQ NAYLEFGFSY INELVDYIKS QYPDIPVIVF 250 260 270 280 290 300 PKGISGFLNK IGGKFDVFGV DWSTPLKMAK ETLGSRYVLQ GNMEPTRLYS KDAIDDGVDE 310 320 330 340 ILSIMRGHRH IFNLGHGILP DVPVENAKYF IKSVQEKSAK YCK

References

[1]	"Sequence of Campylobacter fetus subsp. fetus 82-40." Fouts D.E., Nelson K.E. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 82-40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000487 Genomic DNA. Translation: ABK82820.1.
RefSeq	YP_892592.1. NC_008599.1.
3D structure databases
ProteinModelPortal	A0RQV9.
ModBase	Search...
Protein-protein interaction databases
STRING	A0RQV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4537787.
GenomeReviews	Gene locus CFF8240_1456 in contig CP000487_GR.
KEGG	cff:CFF8240_1456.
NMPDR	fig|360106.5.peg.1391.
PATRIC	20037432. VBICamFet25865_1417.
TIGR	CFF8240_1456.
Phylogenomic databases
eggNOG	COG0407.
HOGENOM	HBG628392.
OMA	PRIHFGV.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	CFET360106:CFF8240_1456-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_CAMFF

Accession

Primary (citable) accession number: A0RQV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program