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A0RQM8

- PANC_CAMFF

UniProt

A0RQM8 - PANC_CAMFF

Protein

Pantothenate synthetase

Gene

panC

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341Proton donorUniRule annotation
    Binding sitei58 – 581Beta-alanineUniRule annotation
    Binding sitei58 – 581PantoateUniRule annotation
    Binding sitei150 – 1501PantoateUniRule annotation
    Binding sitei173 – 1731ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 348ATPUniRule annotation
    Nucleotide bindingi144 – 1474ATPUniRule annotation
    Nucleotide bindingi181 – 1844ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCFET360106:GHTH-1368-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:CFF8240_1370
    OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
    Taxonomic identifieri360106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000760: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Pantothenate synthetasePRO_0000305420Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi360106.CFF8240_1370.

    Structurei

    3D structure databases

    ProteinModelPortaliA0RQM8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175517.
    KOiK01918.
    OMAiEIDYVEV.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0RQM8-1 [UniParc]FASTAAdd to Basket

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    MQILKSVSEL LEFRNNCGGS VGFVPTMGAL HNGHATLIKN SVSQNDDTIV    50
    SVFVNPTQFL PGEDLEKYPR NQSGDIKICE LCGASALFFP NADEIYSKDE 100
    PLIIAPKRIS TILEGATRPG HFDGVCMVLN KLFNLVSPTR AYFGKKDSQQ 150
    LVIVQNMVKR FFLNLEIVPC DIVRESDGLA LSSRNSYLND DELCYALKLS 200
    RSLMRASNLI KANELNSNII KSSMSECLEP LKVDYIAVVD RNFEPIENVE 250
    IGNSIILVAA YVGKTRLIDN IWI 273
    Length:273
    Mass (Da):30,337
    Last modified:January 9, 2007 - v1
    Checksum:iDA174D95E9C8E59B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK81959.1.
    RefSeqiYP_892511.1. NC_008599.1.

    Genome annotation databases

    EnsemblBacteriaiABK81959; ABK81959; CFF8240_1370.
    GeneIDi4538844.
    KEGGicff:CFF8240_1370.
    PATRICi20037258. VBICamFet25865_1333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK81959.1 .
    RefSeqi YP_892511.1. NC_008599.1.

    3D structure databases

    ProteinModelPortali A0RQM8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360106.CFF8240_1370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK81959 ; ABK81959 ; CFF8240_1370 .
    GeneIDi 4538844.
    KEGGi cff:CFF8240_1370.
    PATRICi 20037258. VBICamFet25865_1333.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175517.
    KOi K01918.
    OMAi EIDYVEV.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci CFET360106:GHTH-1368-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
      Fouts D.E., Nelson K.E.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 82-40.

    Entry informationi

    Entry nameiPANC_CAMFF
    AccessioniPrimary (citable) accession number: A0RQM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3