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A0RQK7

- LEU1_CAMFF

UniProt

A0RQK7 - LEU1_CAMFF

Protein

2-isopropylmalate synthase

Gene

leuA

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).UniRule annotation

    Catalytic activityi

    Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-isopropylmalate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. leucine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesis

    Enzyme and pathway databases

    BioCyciCFET360106:GHTH-1342-MONOMER.
    UniPathwayiUPA00048; UER00070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-isopropylmalate synthaseUniRule annotation (EC:2.3.3.13UniRule annotation)
    Alternative name(s):
    Alpha-IPM synthaseUniRule annotation
    Alpha-isopropylmalate synthaseUniRule annotation
    Gene namesi
    Name:leuAUniRule annotation
    Ordered Locus Names:CFF8240_1344
    OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
    Taxonomic identifieri360106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000760: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5065062-isopropylmalate synthasePRO_1000149159Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi360106.CFF8240_1344.

    Structurei

    3D structure databases

    ProteinModelPortaliA0RQK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0119.
    HOGENOMiHOG000046859.
    KOiK01649.
    OMAiEGQNALG.
    OrthoDBiEOG6CGCF3.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01025. LeuA_type1.
    InterProiIPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR005671. LeuA_bact_synth.
    IPR000891. PYR_CT.
    [Graphical view]
    PfamiPF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view]
    SMARTiSM00917. LeuA_dimer. 1 hit.
    [Graphical view]
    SUPFAMiSSF110921. SSF110921. 1 hit.
    TIGRFAMsiTIGR00973. leuA_bact. 1 hit.
    PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0RQK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNNKIIVFD TTLRDGEQSP GASMNTEEKI QIALQLERLG VDVMEAGFAA    50
    ASPGDFDAIN QIAKQIHSIR IASLARALEK DIKAAGEAIS PAKNRRIHTF 100
    IATSPIHMEH KLKMTPDEVI KRAVEAVKYA KTFVDDVEFS CEDAGRSDIV 150
    FLKEICAAVV EAGARTLNLP DTVGFRMPDE IYNMVKSMVD FIGDRAIISV 200
    HNHNDLGLAV ANTLASIKAG ARQVECTING LGERAGNAAL EEIVMTIRTR 250
    SDEFAPLYTD IVTKEIYATS RLVASITGIE PQPNKAIVGK NAFAHESGIH 300
    QDGMLKCAQT YEIIKAEDIG AEKNSLVLGK HSGRHAFKDK LINLGFDLDD 350
    NEINEAFIKF KELCDKKKEI FDDDIRALVS HEIIKIPEIY SIQTLSTSSC 400
    NAGHSSAAVS IKFSDNIISD AALGNGTADA IFKVIDRISG ISGELKDYKV 450
    NAVSQGKDAL AKITVKVVFE GSSCATIGHG LDIDTMMASA KAYVSALNSY 500
    LSMKNR 506
    Length:506
    Mass (Da):54,896
    Last modified:January 9, 2007 - v1
    Checksum:iEA0FBEE7E49F01E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK82096.1.
    RefSeqiYP_892490.1. NC_008599.1.

    Genome annotation databases

    EnsemblBacteriaiABK82096; ABK82096; CFF8240_1344.
    GeneIDi4539073.
    KEGGicff:CFF8240_1344.
    PATRICi20037206. VBICamFet25865_1308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK82096.1 .
    RefSeqi YP_892490.1. NC_008599.1.

    3D structure databases

    ProteinModelPortali A0RQK7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360106.CFF8240_1344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK82096 ; ABK82096 ; CFF8240_1344 .
    GeneIDi 4539073.
    KEGGi cff:CFF8240_1344.
    PATRICi 20037206. VBICamFet25865_1308.

    Phylogenomic databases

    eggNOGi COG0119.
    HOGENOMi HOG000046859.
    KOi K01649.
    OMAi EGQNALG.
    OrthoDBi EOG6CGCF3.

    Enzyme and pathway databases

    UniPathwayi UPA00048 ; UER00070 .
    BioCyci CFET360106:GHTH-1342-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01025. LeuA_type1.
    InterProi IPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR005671. LeuA_bact_synth.
    IPR000891. PYR_CT.
    [Graphical view ]
    Pfami PF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view ]
    SMARTi SM00917. LeuA_dimer. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110921. SSF110921. 1 hit.
    TIGRFAMsi TIGR00973. leuA_bact. 1 hit.
    PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
      Fouts D.E., Nelson K.E.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 82-40.

    Entry informationi

    Entry nameiLEU1_CAMFF
    AccessioniPrimary (citable) accession number: A0RQK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3