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A0RQD0

- PNP_CAMFF

UniProt

A0RQD0 - PNP_CAMFF

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi515 – 5151MagnesiumUniRule annotation
Metal bindingi521 – 5211MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCFET360106:GHTH-1255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CFF8240_1257
OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
Taxonomic identifieri360106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000760: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Polyribonucleotide nucleotidyltransferasePRO_0000329569Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360106.CFF8240_1257.

Structurei

3D structure databases

ProteinModelPortaliA0RQD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini581 – 64161KHUniRule annotationAdd
BLAST
Domaini669 – 72860S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RQD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQCSIEVNNQ IEIFDLNKVA KQAAGAVLMR VKNTVVLAAV AREDAQVEED
60 70 80 90 100
FLPLTVQYIE KQYAAGRIPG GYVKRETKPG DFETLTSRII DRSLRPLFPK
110 120 130 140 150
GYAYPTQIVV MVLSSDPEVD LQVVSLNAAS VALYLSDIPV NSPVCGVRVG
160 170 180 190 200
HINGKFVINP SNSELKNSAL DLYVAGVKDE LLMIEMRSLP NEQNEIVPVI
210 220 230 240 250
AIDPMMDPSL NEGFVSRQKM NEFSEDLMID AIKLATEAIL KGSNAYEEAF
260 270 280 290 300
RNYKKETANL EYKPEIENEN VAIYINEFYK EDVKAAINQM AKSERASELS
310 320 330 340 350
KIAKQIALSE VAQKEGWDEA LISNILGKYK KKLVRTGIIK DKKRADGRGL
360 370 380 390 400
KDVRPISIET NILPNAHGSC LFTRGQTQAL VVTTLGTDND AQMSEYLTEK
410 420 430 440 450
NAVADKFMFN YNFPGFSVGE ASPLKAPGRR ELGHGNLAKR ALYPSIDLNS
460 470 480 490 500
PYSLRVVSEI LESNGSSSMA SVCGGSLSLR AAGVETIKLV AGVAMGLVFE
510 520 530 540 550
GDEHAVLTDI MGLEDHDGDM DFKVAGSKDG ITALQMDIKL GGISLDVLKE
560 570 580 590 600
ALYQAKEARD HILNLMVKAD EEIVVNEDVL PKLELFSVDP SKIVDIIGQA
610 620 630 640 650
GKTIKEIIEK FEVSIDLDRD KGEVKIAGGE RQKVEAAKDY IIQITQKEQR
660 670 680 690 700
SGGFRNKREY KNVTPFNIGD EFEGEIKKMA AFGAFISLRD GVDGLLHISK
710 720
IVSPLKEGDT IKVKVSDIKG GKISLDLN
Length:728
Mass (Da):79,977
Last modified:January 9, 2007 - v1
Checksum:iD45AD8379361B6B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000487 Genomic DNA. Translation: ABK82230.1.
RefSeqiYP_892413.1. NC_008599.1.

Genome annotation databases

EnsemblBacteriaiABK82230; ABK82230; CFF8240_1257.
GeneIDi4538697.
KEGGicff:CFF8240_1257.
PATRICi20037034. VBICamFet25865_1230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000487 Genomic DNA. Translation: ABK82230.1 .
RefSeqi YP_892413.1. NC_008599.1.

3D structure databases

ProteinModelPortali A0RQD0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360106.CFF8240_1257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK82230 ; ABK82230 ; CFF8240_1257 .
GeneIDi 4538697.
KEGGi cff:CFF8240_1257.
PATRICi 20037034. VBICamFet25865_1230.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CFET360106:GHTH-1255-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
    Fouts D.E., Nelson K.E.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 82-40.

Entry informationi

Entry nameiPNP_CAMFF
AccessioniPrimary (citable) accession number: A0RQD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3