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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi515MagnesiumUniRule annotation1
Metal bindingi521MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CFF8240_1257
OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
Taxonomic identifieri360106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000760 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295691 – 728Polyribonucleotide nucleotidyltransferaseAdd BLAST728

Proteomic databases

PRIDEiA0RQD0

Structurei

3D structure databases

ProteinModelPortaliA0RQD0
SMRiA0RQD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini581 – 641KHUniRule annotationAdd BLAST61
Domaini669 – 728S1 motifUniRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 1 hit
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 2 hits
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A0RQD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCSIEVNNQ IEIFDLNKVA KQAAGAVLMR VKNTVVLAAV AREDAQVEED
60 70 80 90 100
FLPLTVQYIE KQYAAGRIPG GYVKRETKPG DFETLTSRII DRSLRPLFPK
110 120 130 140 150
GYAYPTQIVV MVLSSDPEVD LQVVSLNAAS VALYLSDIPV NSPVCGVRVG
160 170 180 190 200
HINGKFVINP SNSELKNSAL DLYVAGVKDE LLMIEMRSLP NEQNEIVPVI
210 220 230 240 250
AIDPMMDPSL NEGFVSRQKM NEFSEDLMID AIKLATEAIL KGSNAYEEAF
260 270 280 290 300
RNYKKETANL EYKPEIENEN VAIYINEFYK EDVKAAINQM AKSERASELS
310 320 330 340 350
KIAKQIALSE VAQKEGWDEA LISNILGKYK KKLVRTGIIK DKKRADGRGL
360 370 380 390 400
KDVRPISIET NILPNAHGSC LFTRGQTQAL VVTTLGTDND AQMSEYLTEK
410 420 430 440 450
NAVADKFMFN YNFPGFSVGE ASPLKAPGRR ELGHGNLAKR ALYPSIDLNS
460 470 480 490 500
PYSLRVVSEI LESNGSSSMA SVCGGSLSLR AAGVETIKLV AGVAMGLVFE
510 520 530 540 550
GDEHAVLTDI MGLEDHDGDM DFKVAGSKDG ITALQMDIKL GGISLDVLKE
560 570 580 590 600
ALYQAKEARD HILNLMVKAD EEIVVNEDVL PKLELFSVDP SKIVDIIGQA
610 620 630 640 650
GKTIKEIIEK FEVSIDLDRD KGEVKIAGGE RQKVEAAKDY IIQITQKEQR
660 670 680 690 700
SGGFRNKREY KNVTPFNIGD EFEGEIKKMA AFGAFISLRD GVDGLLHISK
710 720
IVSPLKEGDT IKVKVSDIKG GKISLDLN
Length:728
Mass (Da):79,977
Last modified:January 9, 2007 - v1
Checksum:iD45AD8379361B6B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000487 Genomic DNA Translation: ABK82230.1
RefSeqiWP_002850035.1, NC_008599.1

Genome annotation databases

EnsemblBacteriaiABK82230; ABK82230; CFF8240_1257
KEGGicff:CFF8240_1257

Similar proteinsi

Entry informationi

Entry nameiPNP_CAMFF
AccessioniPrimary (citable) accession number: A0RQD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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