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A0RQD0

- PNP_CAMFF

UniProt

A0RQD0 - PNP_CAMFF

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, CFF8240_1257
Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi515 – 5151Magnesium By similarity
Metal bindingi521 – 5211Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCFET360106:GHTH-1255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:CFF8240_1257
OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
Taxonomic identifieri360106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000760: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329569Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360106.CFF8240_1257.

Structurei

3D structure databases

ProteinModelPortaliA0RQD0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini581 – 64161KH
Add
BLAST
Domaini669 – 72860S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RQD0-1 [UniParc]FASTAAdd to Basket

« Hide

MQCSIEVNNQ IEIFDLNKVA KQAAGAVLMR VKNTVVLAAV AREDAQVEED    50
FLPLTVQYIE KQYAAGRIPG GYVKRETKPG DFETLTSRII DRSLRPLFPK 100
GYAYPTQIVV MVLSSDPEVD LQVVSLNAAS VALYLSDIPV NSPVCGVRVG 150
HINGKFVINP SNSELKNSAL DLYVAGVKDE LLMIEMRSLP NEQNEIVPVI 200
AIDPMMDPSL NEGFVSRQKM NEFSEDLMID AIKLATEAIL KGSNAYEEAF 250
RNYKKETANL EYKPEIENEN VAIYINEFYK EDVKAAINQM AKSERASELS 300
KIAKQIALSE VAQKEGWDEA LISNILGKYK KKLVRTGIIK DKKRADGRGL 350
KDVRPISIET NILPNAHGSC LFTRGQTQAL VVTTLGTDND AQMSEYLTEK 400
NAVADKFMFN YNFPGFSVGE ASPLKAPGRR ELGHGNLAKR ALYPSIDLNS 450
PYSLRVVSEI LESNGSSSMA SVCGGSLSLR AAGVETIKLV AGVAMGLVFE 500
GDEHAVLTDI MGLEDHDGDM DFKVAGSKDG ITALQMDIKL GGISLDVLKE 550
ALYQAKEARD HILNLMVKAD EEIVVNEDVL PKLELFSVDP SKIVDIIGQA 600
GKTIKEIIEK FEVSIDLDRD KGEVKIAGGE RQKVEAAKDY IIQITQKEQR 650
SGGFRNKREY KNVTPFNIGD EFEGEIKKMA AFGAFISLRD GVDGLLHISK 700
IVSPLKEGDT IKVKVSDIKG GKISLDLN 728
Length:728
Mass (Da):79,977
Last modified:January 9, 2007 - v1
Checksum:iD45AD8379361B6B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000487 Genomic DNA. Translation: ABK82230.1.
RefSeqiYP_892413.1. NC_008599.1.

Genome annotation databases

EnsemblBacteriaiABK82230; ABK82230; CFF8240_1257.
GeneIDi4538697.
KEGGicff:CFF8240_1257.
PATRICi20037034. VBICamFet25865_1230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000487 Genomic DNA. Translation: ABK82230.1 .
RefSeqi YP_892413.1. NC_008599.1.

3D structure databases

ProteinModelPortali A0RQD0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360106.CFF8240_1257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK82230 ; ABK82230 ; CFF8240_1257 .
GeneIDi 4538697.
KEGGi cff:CFF8240_1257.
PATRICi 20037034. VBICamFet25865_1230.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CFET360106:GHTH-1255-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
    Fouts D.E., Nelson K.E.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 82-40.

Entry informationi

Entry nameiPNP_CAMFF
AccessioniPrimary (citable) accession number: A0RQD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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