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A0RQ93

- TRMB_CAMFF

UniProt

A0RQ93 - TRMB_CAMFF

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, CFF8240_1218
Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261S-adenosyl-L-methionine By similarity
Binding sitei151 – 1511S-adenosyl-L-methionine By similarity
Binding sitei178 – 1781S-adenosyl-L-methionine By similarity
Binding sitei204 – 2041Substrate By similarity
Binding sitei234 – 2341Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCFET360106:GHTH-1216-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:CFF8240_1218
    OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
    Taxonomic identifieri360106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000760: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288132Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360106.CFF8240_1218.

    Structurei

    3D structure databases

    ProteinModelPortaliA0RQ93.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000252163.
    KOiK03439.
    OMAiSKYEARW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0RQ93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNFVATSLK NLKFPFGADG VEFLWSAKAG DESLIYTKTG KKEFFLLVKD    50
    KKTEFVVKSD KLTRPASLGT IQKALSVYKD LNVLDLKSST IAIKNEKQLA 100
    KKEFILNDIQ FLEKLKSGEF KKIFVEIGFG SGRHLLYQAK TDENTLVVGI 150
    EVYKRSCEQV NNLALSMGLK NVILLNLDAR LVMSLLHSNS VDRLFLHFPV 200
    PWEKSEKRRV VSAEFANECQ RVLKSGGSFE LRSDDKNYTD FTISCFLNLK 250
    EAKMEIYKNR FLDVSSKYED RWIKQNRDIY DVVFTNLIVS EQKVLHGDFE 300
    FGTVLEEDIL SKFENKTIKK DDYFIHMERI YKKDSSEKNG GLLLRVAFGS 350
    FYRPEHCFIL VENSKASYFI KKPLLTYENL KAHSTLKEYL SCSTS 395
    Length:395
    Mass (Da):45,516
    Last modified:January 9, 2007 - v1
    Checksum:iB46D6A5ACF835BD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK82983.1.
    RefSeqiYP_892376.1. NC_008599.1.

    Genome annotation databases

    EnsemblBacteriaiABK82983; ABK82983; CFF8240_1218.
    GeneIDi4538618.
    KEGGicff:CFF8240_1218.
    PATRICi20036954. VBICamFet25865_1191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK82983.1 .
    RefSeqi YP_892376.1. NC_008599.1.

    3D structure databases

    ProteinModelPortali A0RQ93.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 360106.CFF8240_1218.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK82983 ; ABK82983 ; CFF8240_1218 .
    GeneIDi 4538618.
    KEGGi cff:CFF8240_1218.
    PATRICi 20036954. VBICamFet25865_1191.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000252163.
    KOi K03439.
    OMAi SKYEARW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CFET360106:GHTH-1216-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
      Fouts D.E., Nelson K.E.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 82-40.

    Entry informationi

    Entry nameiTRMB_CAMFF
    AccessioniPrimary (citable) accession number: A0RQ93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: January 9, 2007
    Last modified: June 11, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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