A0RPV9 (ARGB_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	CFF8240_1081

Organism

Campylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]

Taxonomic identifier

360106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000010493
Regions
	Region	64 – 65	2	Substrate binding By similarity
Sites
	Binding site	86	1	Substrate By similarity
	Binding site	179	1	Substrate By similarity
	Site	29	1	Transition state stabilizer By similarity
	Site	239	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0RPV9 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: A0EBE1A8501B6661	FASTA	280	30,317
	10 20 30 40 50 60 MLKSIRTAEI ILSALPYIQK FRDEIFVIKY GGAAQIDEKL KNNFARDIVL LQLVGIKAVI 70 80 90 100 110 120 VHGGGKKINS FLERLNLKSE FIDGLRVTDK DAMEVVEMTL SGLINKEITS LLNKHGARAI 130 140 150 160 170 180 GISGKDDNML KAKSLDDGKY GFVGEITDVN ENVILTIIND GLIPVIAPIA IGSEYETYNI 190 200 210 220 230 240 NADLCASAIA SKLKARKVIF LSDIKGVLDK DEKLISKLNE TSINELKNNG AISGGMIPKI 250 260 270 280 DACLECIKSG VGAAHIIDGK IPHSLLLEIF TDEGIGSVIK

References

[1]	"Sequence of Campylobacter fetus subsp. fetus 82-40." Fouts D.E., Nelson K.E. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 82-40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000487 Genomic DNA. Translation: ABK81796.1.
RefSeq	YP_892242.1. NC_008599.1.
3D structure databases
ProteinModelPortal	A0RPV9.
ModBase	Search...
Protein-protein interaction databases
STRING	A0RPV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4538037.
GenomeReviews	Gene locus CFF8240_1081 in contig CP000487_GR.
KEGG	cff:CFF8240_1081.
NMPDR	fig|360106.5.peg.1033.
PATRIC	20036678. VBICamFet25865_1053.
TIGR	CFF8240_1081.
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGNAMID.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	CFET360106:CFF8240_1081-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_CAMFF

Accession

Primary (citable) accession number: A0RPV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program