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A0RP26 (DAPA_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:CFF8240_0784
OrganismCampylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]
Taxonomic identifier360106 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000340940

Regions

Region50 – 512Pyruvate binding By similarity

Sites

Active site1651Schiff-base intermediate with substrate By similarity
Binding site1091Pyruvate By similarity
Site1361Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
A0RP26 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: D6550ADC86643A18

FASTA29732,506
        10         20         30         40         50         60 
MKKAIFGAMT ALITPFKNGK LDEAGYEKLI KRQIKNGIDA IVPVGTTGES ATLTHDEHRI 

        70         80         90        100        110        120 
CIEIAVETCK NTKVKVLAGA GSNATHEAVD LAEFAEAHGA DGILSVAPYY NKPTQEGLYL 

       130        140        150        160        170        180 
HYKNIANSVK IPVLLYNVPG RTGCDILPET VIRLFNDCEN IYGVKEASGS IDRCVDLLAH 

       190        200        210        220        230        240 
EPKLYVLSGE DAINYPILSN GGKGVISVTS NLLPDQTAAL THYALDNEFL KAKEINDRLY 

       250        260        270        280        290 
NINKIMFCES NPIPIKAAMF IAGLIDTLEY RLPLCNPSVD NLKKIEETMK SYDIKGF

« Hide

References

[1]"Sequence of Campylobacter fetus subsp. fetus 82-40."
Fouts D.E., Nelson K.E.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 82-40.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000487 Genomic DNA. Translation: ABK82563.1.
RefSeqYP_891959.1. NC_008599.1.

3D structure databases

ProteinModelPortalA0RP26.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0RP26.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4538939.
GenomeReviewsGene locus CFF8240_0784 in contig CP000487_GR.
KEGGcff:CFF8240_0784.
NMPDRfig|360106.5.peg.744.
PATRIC20036084. VBICamFet25865_0758.
TIGRCFF8240_0784.

Phylogenomic databases

eggNOGCOG0329.
HOGENOMHBG358848.
OMAFMLCGGH.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycCFET360106:CFF8240_0784-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_CAMFF
AccessionPrimary (citable) accession number: A0RP26
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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