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A0RNX3

- SYL_CAMFF

UniProt

A0RNX3 - SYL_CAMFF

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei582 – 5821ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCFET360106:GHTH-730-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CFF8240_0731
    OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
    Taxonomic identifieri360106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000760: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 811811Leucine--tRNA ligasePRO_1000009316Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360106.CFF8240_0731.

    Structurei

    3D structure databases

    ProteinModelPortaliA0RNX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi579 – 5835"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0RNX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNAKNIEY KWQQIWKKNG YSEPKDDYSL PKKYILSMFP YPSGRLHMGH    50
    VRNYSIGDAL SRYYRNRGYN VLQPIGFDSF GMPAENAAIK HKIHPKIWTY 100
    DNIDYMTKEL DALGFSFSKK RLFATSDPLY TRWEQEFFIR MYEKGLVYRK 150
    SAVVNWCEND QTVLANEQVE DGKCWRCGHE VIQKEMPGYY LKITDYANEL 200
    LECLKDLEGK WPNQVLTMQE NWIGKSYGLE FEFKFDSSSK ILLDGMDGFK 250
    VFTTRPDTIY GVSYAAIAPE HIVVKKLLEK NILDDATSAK LKFILNQSPK 300
    QRQSIDKDGV SLGLNVIHPL TNELIPVWCA NFVLAEYGGG AVMSVPAHDE 350
    RDFEFASKFN LNIKQIIKSD TLPYCEKSGV YINSELINGL AYEEAREKII 400
    SKFEKEGWGN RVTNYKLRDW GISRQRYWGA PIPMIHCKKC GVVPENISNL 450
    PVKLPDDVVI TGEGNPLDKH SEFKNCKCPK CGSQATRETD TMDTFFESSW 500
    YFARFASDEK TWEDVAFDKK SVDYWMSVDQ YIGGIEHAIL HLLYARFFQK 550
    ALRDLGYLRD CEPFDSLLTQ GMVLKDGSKM SKSKGNTVDP DDIINKFGAD 600
    TARLFILFAA PPQKELEWND SAVEGAFKFI NRLYDRSDNA YKTEILPQIN 650
    HSNLNKDEKY ARLKVYEALK KSTDVFENSF AFNTLIAACM EALNGLNAQN 700
    NKDIWTEGYF IILNLLEPII PHACHELSNE LFGLKNFTKL SLKDEVFVKD 750
    SLNLAITVNG KRRSEIEVSA FESDDKILEI AKQEVSKWIE GKEILKEIYV 800
    PNKLVNLVIK G 811
    Length:811
    Mass (Da):93,325
    Last modified:January 9, 2007 - v1
    Checksum:i7A2CFDF0E6B32A25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK82789.1.
    RefSeqiWP_002849157.1. NC_008599.1.
    YP_891906.1. NC_008599.1.

    Genome annotation databases

    EnsemblBacteriaiABK82789; ABK82789; CFF8240_0731.
    GeneIDi4539205.
    KEGGicff:CFF8240_0731.
    PATRICi20035978. VBICamFet25865_0705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK82789.1 .
    RefSeqi WP_002849157.1. NC_008599.1.
    YP_891906.1. NC_008599.1.

    3D structure databases

    ProteinModelPortali A0RNX3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360106.CFF8240_0731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK82789 ; ABK82789 ; CFF8240_0731 .
    GeneIDi 4539205.
    KEGGi cff:CFF8240_0731.
    PATRICi 20035978. VBICamFet25865_0705.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CFET360106:GHTH-730-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
      Fouts D.E., Nelson K.E.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 82-40.

    Entry informationi

    Entry nameiSYL_CAMFF
    AccessioniPrimary (citable) accession number: A0RNX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3