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A0RNX3

- SYL_CAMFF

UniProt

A0RNX3 - SYL_CAMFF

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei582 – 5821ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCFET360106:GHTH-730-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CFF8240_0731
OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
Taxonomic identifieri360106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000760: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Leucine--tRNA ligasePRO_1000009316Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360106.CFF8240_0731.

Structurei

3D structure databases

ProteinModelPortaliA0RNX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionAdd
BLAST
Motifi579 – 5835"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RNX3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYNAKNIEY KWQQIWKKNG YSEPKDDYSL PKKYILSMFP YPSGRLHMGH
60 70 80 90 100
VRNYSIGDAL SRYYRNRGYN VLQPIGFDSF GMPAENAAIK HKIHPKIWTY
110 120 130 140 150
DNIDYMTKEL DALGFSFSKK RLFATSDPLY TRWEQEFFIR MYEKGLVYRK
160 170 180 190 200
SAVVNWCEND QTVLANEQVE DGKCWRCGHE VIQKEMPGYY LKITDYANEL
210 220 230 240 250
LECLKDLEGK WPNQVLTMQE NWIGKSYGLE FEFKFDSSSK ILLDGMDGFK
260 270 280 290 300
VFTTRPDTIY GVSYAAIAPE HIVVKKLLEK NILDDATSAK LKFILNQSPK
310 320 330 340 350
QRQSIDKDGV SLGLNVIHPL TNELIPVWCA NFVLAEYGGG AVMSVPAHDE
360 370 380 390 400
RDFEFASKFN LNIKQIIKSD TLPYCEKSGV YINSELINGL AYEEAREKII
410 420 430 440 450
SKFEKEGWGN RVTNYKLRDW GISRQRYWGA PIPMIHCKKC GVVPENISNL
460 470 480 490 500
PVKLPDDVVI TGEGNPLDKH SEFKNCKCPK CGSQATRETD TMDTFFESSW
510 520 530 540 550
YFARFASDEK TWEDVAFDKK SVDYWMSVDQ YIGGIEHAIL HLLYARFFQK
560 570 580 590 600
ALRDLGYLRD CEPFDSLLTQ GMVLKDGSKM SKSKGNTVDP DDIINKFGAD
610 620 630 640 650
TARLFILFAA PPQKELEWND SAVEGAFKFI NRLYDRSDNA YKTEILPQIN
660 670 680 690 700
HSNLNKDEKY ARLKVYEALK KSTDVFENSF AFNTLIAACM EALNGLNAQN
710 720 730 740 750
NKDIWTEGYF IILNLLEPII PHACHELSNE LFGLKNFTKL SLKDEVFVKD
760 770 780 790 800
SLNLAITVNG KRRSEIEVSA FESDDKILEI AKQEVSKWIE GKEILKEIYV
810
PNKLVNLVIK G
Length:811
Mass (Da):93,325
Last modified:January 9, 2007 - v1
Checksum:i7A2CFDF0E6B32A25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000487 Genomic DNA. Translation: ABK82789.1.
RefSeqiYP_891906.1. NC_008599.1.

Genome annotation databases

EnsemblBacteriaiABK82789; ABK82789; CFF8240_0731.
GeneIDi4539205.
KEGGicff:CFF8240_0731.
PATRICi20035978. VBICamFet25865_0705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000487 Genomic DNA. Translation: ABK82789.1 .
RefSeqi YP_891906.1. NC_008599.1.

3D structure databases

ProteinModelPortali A0RNX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360106.CFF8240_0731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK82789 ; ABK82789 ; CFF8240_0731 .
GeneIDi 4539205.
KEGGi cff:CFF8240_0731.
PATRICi 20035978. VBICamFet25865_0705.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CFET360106:GHTH-730-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
    Fouts D.E., Nelson K.E.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 82-40.

Entry informationi

Entry nameiSYL_CAMFF
AccessioniPrimary (citable) accession number: A0RNX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3