Skip Header

Contribute Send feedback
Read comments (?) or add your own

A0RNU4 (HEMH_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:CFF8240_0703
OrganismCampylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]
Taxonomic identifier360106 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Ferrochelatase HAMAP MF_00323
PRO_1000119603

Sites

Metal binding1881Iron By similarity
Metal binding2691Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A0RNU4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 58C129CB2D475FAD

FASTA31436,077
        10         20         30         40         50         60 
MKKVVILLNM GGADDLSQVE LFLKNMFNDP YILGIKNRKI RSVLAWLITK MRLKSATRNY 

        70         80         90        100        110        120 
TELGGKSPIG DITRSLIDKL NIKFGNENLT FDYAMNYTPP FAIDSLKKYK YADEILLFPL 

       130        140        150        160        170        180 
YPHHSRTTIV SSLDSANRAI KELSIKSNIK VINYFYKDER YNKIITSSIK EKIAEMNSSQ 

       190        200        210        220        230        240 
IDLIFSSHSL PKKIIEKGDL YETHTNEHVK IISDMLAKDG VKFNSISLAY QSRLGPVEWL 

       250        260        270        280        290        300 
GPNLSEVLSN LKSKKALIYP ISFCIDNSET DFELDIEYRK IADQKEFDYY EVVKAPDDSE 

       310 
AFVDYIAYKV KELV

« Hide

References

[1]"Sequence of Campylobacter fetus subsp. fetus 82-40."
Fouts D.E., Nelson K.E.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 82-40.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000487 Genomic DNA. Translation: ABK82735.1.
RefSeqYP_891877.1. NC_008599.1.

3D structure databases

ProteinModelPortalA0RNU4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0RNU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4538174.
GenomeReviewsGene locus CFF8240_0703 in contig CP000487_GR.
KEGGcff:CFF8240_0703.
NMPDRfig|360106.5.peg.664.
PATRIC20035920. VBICamFet25865_0676.
TIGRCFF8240_0703.

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALLQMGGP.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycCFET360106:CFF8240_0703-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_CAMFF
AccessionPrimary (citable) accession number: A0RNU4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents