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A0RNS3 (PDXA_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:CFF8240_0681
OrganismCampylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]
Taxonomic identifier360106 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3073074-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_1000051492

Sites

Metal binding1501Divalent metal cation; shared with dimeric partner By similarity
Metal binding1891Divalent metal cation; shared with dimeric partner By similarity
Metal binding2461Divalent metal cation; shared with dimeric partner By similarity
Binding site1211Substrate By similarity
Binding site1221Substrate By similarity
Binding site2541Substrate By similarity
Binding site2631Substrate By similarity
Binding site2721Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A0RNS3 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: A3439845911CFA96

FASTA30733,925
        10         20         30         40         50         60 
MSLPKIAISV GDINGVGIEI ALKSHDEIKN ICSPIYFINN ELLNSAANIL KFTVPNDFEI 

        70         80         90        100        110        120 
FECGSSFNIK PGRVSKKSGK FSFVSFENAI LYTQNKRAQA LVTMPINKES WKKAGVPYVG 

       130        140        150        160        170        180 
HTDALGKYFG KNAIMMLGCE ELFVALYTDH LALKDVSAKI KAKNLALFLV DFYNSSKFEN 

       190        200        210        220        230        240 
IGVLGFNPHA SDNETIGGKE EKEIIKAIKS ANNRLKKEVF TGPLVPDAAF TKSSLKRCNR 

       250        260        270        280        290        300 
LVSMYHDVGL APLKALYFDK SINVSLNLPI VRTSVDHGTA FDIAYKGKAE TKSYIEAIKF 


AIKLCDY 

« Hide

References

[1]"Sequence of Campylobacter fetus subsp. fetus 82-40."
Fouts D.E., Nelson K.E.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 82-40.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000487 Genomic DNA. Translation: ABK83061.1.
RefSeqYP_891856.1. NC_008599.1.

3D structure databases

ProteinModelPortalA0RNS3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360106.CFF8240_0681.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK83061; ABK83061; CFF8240_0681.
GeneID4538213.
KEGGcff:CFF8240_0681.
PATRIC20035880. VBICamFet25865_0656.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221591.
KOK00097.
OMAAPINKHN.
OrthoDBEOG6GN6ZC.

Enzyme and pathway databases

BioCycCFET360106:GHTH-680-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_CAMFF
AccessionPrimary (citable) accession number: A0RNS3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways