A0RMR7 (DAPB_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	CFF8240_0298

Organism

Campylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]

Taxonomic identifier

360106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008551

Sequences

	Sequence		Length	Mass (Da)
	A0RMR7 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 9A8D9243A5FB0A82	FASTA	254	27,421
	10 20 30 40 50 60 MIRIGIHGAS GKMGYEIISN LKNNEQAILS VAYTIEPMPF DVGDAIVTND LKTLFDNSDV 70 80 90 100 110 120 IIDFSIKDGA VNLINYARTN PKPLIIGTTG LGSEGDELIK LASSVMPILQ ATNMSLGVAV 130 140 150 160 170 180 LNRLTEFASR VLDGFDIEIV EMHHRRKVDA PSGTALTLAT HAAKARNLTL DSVRVSGRDG 190 200 210 220 230 240 MIGARSKDEI AVMSLRGGDI VGRHTVGFYN DGEFIELNHT ATSRATFAKG AIKAAIWIKS 250 KEPKLYSIYD CLGL

References

[1]	"Sequence of Campylobacter fetus subsp. fetus 82-40." Fouts D.E., Nelson K.E. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 82-40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000487 Genomic DNA. Translation: ABK81775.1.
RefSeq	YP_891500.1. NC_008599.1.
3D structure databases
ProteinModelPortal	A0RMR7.
ModBase	Search...
Protein-protein interaction databases
STRING	A0RMR7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4538330.
GenomeReviews	Gene locus CFF8240_0298 in contig CP000487_GR.
KEGG	cff:CFF8240_0298.
NMPDR	fig|360106.5.peg.288.
PATRIC	20035122. VBICamFet25865_0293.
TIGR	CFF8240_0298.
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	IEISHKS.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	CFET360106:CFF8240_0298-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_CAMFF

Accession

Primary (citable) accession number: A0RMR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program