A0RMI1 (DXR_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Short name=DXP reductoisomerase
EC=1.1.1.267

Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

Name:	dxr
Ordered Locus Names:	CFF8240_0210

Organism

Campylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]

Taxonomic identifier

360106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183
Catalytic activity	2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183
Cofactor	Divalent cation By similarity. HAMAP MF_00183
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183
Sequence similarities	Belongs to the DXR family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Ligand	Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Inferred from electronic annotation. Source: EC NADPH binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183		PRO_1000020237
Regions
	Nucleotide binding	4 – 30	27	NADP By similarity
Sites
	Metal binding	135	1	Divalent metal cation By similarity
	Metal binding	137	1	Divalent metal cation By similarity
	Metal binding	204	1	Divalent metal cation By similarity
	Binding site	116	1	Substrate By similarity
	Binding site	137	1	Substrate By similarity
	Binding site	159	1	Substrate By similarity
	Binding site	182	1	Substrate By similarity
	Binding site	204	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0RMI1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: C18FCC960945BEA1	FASTA	360	40,198
	10 20 30 40 50 60 MILLGSSGSI GKNVAFLAMK YGIKLDALAC KTDYKELNSQ ISKFNPKFVY IEDNKLKNLV 70 80 90 100 110 120 EHSRVFTSKD GIDKFLEACY DEFGSTVVIN SLVGFSGLRP SLVSQKLGFK LALANKESLV 130 140 150 160 170 180 AGGKFLDTKS INPIDSEHFG LKFLLKNRPA VKKMIITASG GAFYDMHINE LEFVTAKSAL 190 200 210 220 230 240 KHPNWSMGAK ITIDSATMAN KLFEVLEAYH LYGIKDIDAF IERTSCIHAL ISFMDGSTTA 250 260 270 280 290 300 HISRTDMKLA IAHAIGLEEK EILEPIDILS LKNISFNTIN LKKYPIFTLK KDVLNNPDLG 310 320 330 340 350 360 VIINAANEEM VYKFLNNEIS FLDINRAVFK SLDKFGSVKI DDEDTVFEID KKVREFCKGF

References

[1]	"Sequence of Campylobacter fetus subsp. fetus 82-40." Fouts D.E., Nelson K.E. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 82-40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000487 Genomic DNA. Translation: ABK82287.1.
RefSeq	YP_891414.1. NC_008599.1.
3D structure databases
ProteinModelPortal	A0RMI1.
ModBase	Search...
Protein-protein interaction databases
STRING	A0RMI1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4539309.
GenomeReviews	Gene locus CFF8240_0210 in contig CP000487_GR.
KEGG	cff:CFF8240_0210.
NMPDR	fig|360106.5.peg.202.
PATRIC	20034946. VBICamFet25865_0205.
TIGR	CFF8240_0210.
Phylogenomic databases
eggNOG	COG0743.
HOGENOM	HBG430762.
OMA	FEVLEAY.
ProtClustDB	PRK05447.
Enzyme and pathway databases
BioCyc	CFET360106:CFF8240_0210-MONOMER.
Family and domain databases
HAMAP	MF_00183. DXP_reductoisom. [Tree]
InterPro	IPR003821. DXP_reductoisomerase. IPR013644. DXP_reductoisomerase_C. IPR013512. DXP_reductoisomerase_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00099.
Pfam	PF08436. DXP_redisom_C. 1 hit. PF02670. DXP_reductoisom. 1 hit. [Graphical view]
PIRSF	PIRSF006205. Dxp_reductismrs. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DXR_CAMFF

Accession

Primary (citable) accession number: A0RMI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program