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A0RME1 (NUON_CAMFF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit N

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit N
NDH-1 subunit N
Gene names
Name:nuoN
Ordered Locus Names:CFF8240_0169
OrganismCampylobacter fetus subsp. fetus (strain 82-40) [Complete proteome] [HAMAP]
Taxonomic identifier360106 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00445

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_00445

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00445.

Sequence similarities

Belongs to the complex I subunit 2 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469NADH-quinone oxidoreductase subunit N HAMAP-Rule MF_00445
PRO_0000391119

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane28 – 4821Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane157 – 17721Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane233 – 25321Helical; Potential
Transmembrane261 – 28121Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane315 – 33521Helical; Potential
Transmembrane361 – 38121Helical; Potential
Transmembrane398 – 41821Helical; Potential
Transmembrane447 – 46721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0RME1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: DD205E11AA381BD5

FASTA46952,082
        10         20         30         40         50         60 
MIALLPFILS LAATFINIFL CVTNISKRYS INLNILFWVI IFISFFIVRS NFSNDFLMDF 

        70         80         90        100        110        120 
ATPFISLDEF SFCFGVVLSA LMIIFLISSF YSDDEKFYKQ EMFALASLAG FGLLAMSLSV 

       130        140        150        160        170        180 
ELILTLIFLE VASISIYAMI AMNSIEYKSV EAAFKYFLLS SFMSAFYLLG AAFVFGVAGS 

       190        200        210        220        230        240 
TKYSFIATGL NSDFLSIIGM ILVLSMMFFK IAIFGFYRWS IDVYYGSNLN IAGFLASAFK 

       250        260        270        280        290        300 
LASFAILIKL CFLYPGNNIE ILQGIFAILA ILSMFAGNLL SLKETNVKKI LIAAGIVHSG 

       310        320        330        340        350        360 
YIFINLSSVG ASVSIYPAIF YLSTYTIVVG FLFAILNGLF GDREIKISDL NGLYKVRPTE 

       370        380        390        400        410        420 
AFAFTVICLS FIGFPYSVGF LGKLFIFSSA VESGKTYLAI FGIINTIFSV YYYLKIIISI 

       430        440        450        460 
YFSENKTALS CADSKKFGLK LLALSSILFI ILEGSGIFSI ISFLNLFIR 

« Hide

References

[1]"Sequence of Campylobacter fetus subsp. fetus 82-40."
Fouts D.E., Nelson K.E.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 82-40.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000487 Genomic DNA. Translation: ABK82541.1.
RefSeqYP_891374.1. NC_008599.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360106.CFF8240_0169.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK82541; ABK82541; CFF8240_0169.
GeneID4539050.
KEGGcff:CFF8240_0169.
PATRIC20034866. VBICamFet25865_0166.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1007.
KOK00343.
OMATELMENS.
OrthoDBEOG64JFNZ.

Enzyme and pathway databases

BioCycCFET360106:GHTH-169-MONOMER.

Family and domain databases

HAMAPMF_00445. NDH1_NuoN_1.
InterProIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUON_CAMFF
AccessionPrimary (citable) accession number: A0RME1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families