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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:CFF8240_0169
OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
Taxonomic identifieri360106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000760 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei101 – 121HelicalUniRule annotationAdd BLAST21
Transmembranei122 – 142HelicalUniRule annotationAdd BLAST21
Transmembranei157 – 177HelicalUniRule annotationAdd BLAST21
Transmembranei194 – 214HelicalUniRule annotationAdd BLAST21
Transmembranei233 – 253HelicalUniRule annotationAdd BLAST21
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei315 – 335HelicalUniRule annotationAdd BLAST21
Transmembranei361 – 381HelicalUniRule annotationAdd BLAST21
Transmembranei398 – 418HelicalUniRule annotationAdd BLAST21
Transmembranei447 – 467HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003911191 – 469NADH-quinone oxidoreductase subunit NAdd BLAST469

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0RME1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK00343.
OMAiVIAMISK.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RME1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIALLPFILS LAATFINIFL CVTNISKRYS INLNILFWVI IFISFFIVRS
60 70 80 90 100
NFSNDFLMDF ATPFISLDEF SFCFGVVLSA LMIIFLISSF YSDDEKFYKQ
110 120 130 140 150
EMFALASLAG FGLLAMSLSV ELILTLIFLE VASISIYAMI AMNSIEYKSV
160 170 180 190 200
EAAFKYFLLS SFMSAFYLLG AAFVFGVAGS TKYSFIATGL NSDFLSIIGM
210 220 230 240 250
ILVLSMMFFK IAIFGFYRWS IDVYYGSNLN IAGFLASAFK LASFAILIKL
260 270 280 290 300
CFLYPGNNIE ILQGIFAILA ILSMFAGNLL SLKETNVKKI LIAAGIVHSG
310 320 330 340 350
YIFINLSSVG ASVSIYPAIF YLSTYTIVVG FLFAILNGLF GDREIKISDL
360 370 380 390 400
NGLYKVRPTE AFAFTVICLS FIGFPYSVGF LGKLFIFSSA VESGKTYLAI
410 420 430 440 450
FGIINTIFSV YYYLKIIISI YFSENKTALS CADSKKFGLK LLALSSILFI
460
ILEGSGIFSI ISFLNLFIR
Length:469
Mass (Da):52,082
Last modified:January 9, 2007 - v1
Checksum:iDD205E11AA381BD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000487 Genomic DNA. Translation: ABK82541.1.
RefSeqiWP_011731721.1. NC_008599.1.

Genome annotation databases

EnsemblBacteriaiABK82541; ABK82541; CFF8240_0169.
GeneIDi4539050.
KEGGicff:CFF8240_0169.
PATRICi20034866. VBICamFet25865_0166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000487 Genomic DNA. Translation: ABK82541.1.
RefSeqiWP_011731721.1. NC_008599.1.

3D structure databases

ProteinModelPortaliA0RME1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK82541; ABK82541; CFF8240_0169.
GeneIDi4539050.
KEGGicff:CFF8240_0169.
PATRICi20034866. VBICamFet25865_0166.

Phylogenomic databases

KOiK00343.
OMAiVIAMISK.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUON_CAMFF
AccessioniPrimary (citable) accession number: A0RME1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.