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A0RME1

- NUON_CAMFF

UniProt

A0RME1 - NUON_CAMFF

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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciCFET360106:GHTH-169-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:CFF8240_0169
OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
Taxonomic identifieri360106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000760: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalUniRule annotationAdd
BLAST
Transmembranei28 – 4821HelicalUniRule annotationAdd
BLAST
Transmembranei70 – 9021HelicalUniRule annotationAdd
BLAST
Transmembranei101 – 12121HelicalUniRule annotationAdd
BLAST
Transmembranei122 – 14221HelicalUniRule annotationAdd
BLAST
Transmembranei157 – 17721HelicalUniRule annotationAdd
BLAST
Transmembranei194 – 21421HelicalUniRule annotationAdd
BLAST
Transmembranei233 – 25321HelicalUniRule annotationAdd
BLAST
Transmembranei261 – 28121HelicalUniRule annotationAdd
BLAST
Transmembranei290 – 31021HelicalUniRule annotationAdd
BLAST
Transmembranei315 – 33521HelicalUniRule annotationAdd
BLAST
Transmembranei361 – 38121HelicalUniRule annotationAdd
BLAST
Transmembranei398 – 41821HelicalUniRule annotationAdd
BLAST
Transmembranei447 – 46721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469NADH-quinone oxidoreductase subunit NPRO_0000391119Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi360106.CFF8240_0169.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
KOiK00343.
OMAiTELMENS.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RME1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIALLPFILS LAATFINIFL CVTNISKRYS INLNILFWVI IFISFFIVRS
60 70 80 90 100
NFSNDFLMDF ATPFISLDEF SFCFGVVLSA LMIIFLISSF YSDDEKFYKQ
110 120 130 140 150
EMFALASLAG FGLLAMSLSV ELILTLIFLE VASISIYAMI AMNSIEYKSV
160 170 180 190 200
EAAFKYFLLS SFMSAFYLLG AAFVFGVAGS TKYSFIATGL NSDFLSIIGM
210 220 230 240 250
ILVLSMMFFK IAIFGFYRWS IDVYYGSNLN IAGFLASAFK LASFAILIKL
260 270 280 290 300
CFLYPGNNIE ILQGIFAILA ILSMFAGNLL SLKETNVKKI LIAAGIVHSG
310 320 330 340 350
YIFINLSSVG ASVSIYPAIF YLSTYTIVVG FLFAILNGLF GDREIKISDL
360 370 380 390 400
NGLYKVRPTE AFAFTVICLS FIGFPYSVGF LGKLFIFSSA VESGKTYLAI
410 420 430 440 450
FGIINTIFSV YYYLKIIISI YFSENKTALS CADSKKFGLK LLALSSILFI
460
ILEGSGIFSI ISFLNLFIR
Length:469
Mass (Da):52,082
Last modified:January 9, 2007 - v1
Checksum:iDD205E11AA381BD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000487 Genomic DNA. Translation: ABK82541.1.
RefSeqiYP_891374.1. NC_008599.1.

Genome annotation databases

EnsemblBacteriaiABK82541; ABK82541; CFF8240_0169.
GeneIDi4539050.
KEGGicff:CFF8240_0169.
PATRICi20034866. VBICamFet25865_0166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000487 Genomic DNA. Translation: ABK82541.1 .
RefSeqi YP_891374.1. NC_008599.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360106.CFF8240_0169.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK82541 ; ABK82541 ; CFF8240_0169 .
GeneIDi 4539050.
KEGGi cff:CFF8240_0169.
PATRICi 20034866. VBICamFet25865_0166.

Phylogenomic databases

eggNOGi COG1007.
KOi K00343.
OMAi TELMENS.
OrthoDBi EOG64JFNZ.

Enzyme and pathway databases

BioCyci CFET360106:GHTH-169-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
    Fouts D.E., Nelson K.E.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 82-40.

Entry informationi

Entry nameiNUON_CAMFF
AccessioniPrimary (citable) accession number: A0RME1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3