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A0RME1

- NUON_CAMFF

UniProt

A0RME1 - NUON_CAMFF

Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciCFET360106:GHTH-169-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit NUniRule annotation
    NDH-1 subunit NUniRule annotation
    Gene namesi
    Name:nuoNUniRule annotation
    Ordered Locus Names:CFF8240_0169
    OrganismiCampylobacter fetus subsp. fetus (strain 82-40)
    Taxonomic identifieri360106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000760: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469NADH-quinone oxidoreductase subunit NPRO_0000391119Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi360106.CFF8240_0169.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalUniRule annotationAdd
    BLAST
    Transmembranei28 – 4821HelicalUniRule annotationAdd
    BLAST
    Transmembranei70 – 9021HelicalUniRule annotationAdd
    BLAST
    Transmembranei101 – 12121HelicalUniRule annotationAdd
    BLAST
    Transmembranei122 – 14221HelicalUniRule annotationAdd
    BLAST
    Transmembranei157 – 17721HelicalUniRule annotationAdd
    BLAST
    Transmembranei194 – 21421HelicalUniRule annotationAdd
    BLAST
    Transmembranei233 – 25321HelicalUniRule annotationAdd
    BLAST
    Transmembranei261 – 28121HelicalUniRule annotationAdd
    BLAST
    Transmembranei290 – 31021HelicalUniRule annotationAdd
    BLAST
    Transmembranei315 – 33521HelicalUniRule annotationAdd
    BLAST
    Transmembranei361 – 38121HelicalUniRule annotationAdd
    BLAST
    Transmembranei398 – 41821HelicalUniRule annotationAdd
    BLAST
    Transmembranei447 – 46721HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    KOiK00343.
    OMAiTELMENS.
    OrthoDBiEOG64JFNZ.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0RME1-1 [UniParc]FASTAAdd to Basket

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    MIALLPFILS LAATFINIFL CVTNISKRYS INLNILFWVI IFISFFIVRS    50
    NFSNDFLMDF ATPFISLDEF SFCFGVVLSA LMIIFLISSF YSDDEKFYKQ 100
    EMFALASLAG FGLLAMSLSV ELILTLIFLE VASISIYAMI AMNSIEYKSV 150
    EAAFKYFLLS SFMSAFYLLG AAFVFGVAGS TKYSFIATGL NSDFLSIIGM 200
    ILVLSMMFFK IAIFGFYRWS IDVYYGSNLN IAGFLASAFK LASFAILIKL 250
    CFLYPGNNIE ILQGIFAILA ILSMFAGNLL SLKETNVKKI LIAAGIVHSG 300
    YIFINLSSVG ASVSIYPAIF YLSTYTIVVG FLFAILNGLF GDREIKISDL 350
    NGLYKVRPTE AFAFTVICLS FIGFPYSVGF LGKLFIFSSA VESGKTYLAI 400
    FGIINTIFSV YYYLKIIISI YFSENKTALS CADSKKFGLK LLALSSILFI 450
    ILEGSGIFSI ISFLNLFIR 469
    Length:469
    Mass (Da):52,082
    Last modified:January 9, 2007 - v1
    Checksum:iDD205E11AA381BD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK82541.1.
    RefSeqiWP_011731721.1. NC_008599.1.
    YP_891374.1. NC_008599.1.

    Genome annotation databases

    EnsemblBacteriaiABK82541; ABK82541; CFF8240_0169.
    GeneIDi4539050.
    KEGGicff:CFF8240_0169.
    PATRICi20034866. VBICamFet25865_0166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000487 Genomic DNA. Translation: ABK82541.1 .
    RefSeqi WP_011731721.1. NC_008599.1.
    YP_891374.1. NC_008599.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360106.CFF8240_0169.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK82541 ; ABK82541 ; CFF8240_0169 .
    GeneIDi 4539050.
    KEGGi cff:CFF8240_0169.
    PATRICi 20034866. VBICamFet25865_0166.

    Phylogenomic databases

    eggNOGi COG1007.
    KOi K00343.
    OMAi TELMENS.
    OrthoDBi EOG64JFNZ.

    Enzyme and pathway databases

    BioCyci CFET360106:GHTH-169-MONOMER.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of Campylobacter fetus subsp. fetus 82-40."
      Fouts D.E., Nelson K.E.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 82-40.

    Entry informationi

    Entry nameiNUON_CAMFF
    AccessioniPrimary (citable) accession number: A0RME1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3