Skip Header

Contribute Send feedback
Read comments (?) or add your own

A0RLN5 (GUAC_BACAH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP reductase
EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:BALH_4963
OrganismBacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]
Taxonomic identifier412694 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328GMP reductase HAMAP MF_01511
PRO_0000292049

Regions

Nucleotide binding205 – 22824NADP Potential

Sites

Active site1761Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
A0RLN5 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 7770C14C1FF1EE72

FASTA32836,303
        10         20         30         40         50         60 
MMENVFDYED IQLIPAKCIV NSRSECDTTV TLGKHKFKLP VVPANMQTII DERIATYLAE 

        70         80         90        100        110        120 
NNYFYIMHRF QPEKRISFIR DMQSRGLIAS ISVGVKEDEY EFVQQLAAEH LTPEYITIDI 

       130        140        150        160        170        180 
AHGHSNAVIN MIQHIKKHLP ESFVIAGNVG TPEAVRELEN AGADATKVGI GPGKVCITKI 

       190        200        210        220        230        240 
KTGFGTGGWQ LAALRWCAKA ASKPIIADGG IRTHGDVAKS IRFGATMVMI GSLFAGHEES 

       250        260        270        280        290        300 
PGETIEKDGK LYKEYFGSAS EFQKGEKKNV EGKKMFVEHK GSLEDTLIEM EQDLQSSISY 

       310        320 
AGGTKLDSIR TVDYVVVKNS IFNGDKVY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000485 Genomic DNA. Translation: ABK88128.1.
RefSeqYP_897635.1. NC_008600.1.

3D structure databases

ProteinModelPortalA0RLN5.
SMRA0RLN5. Positions 2-322.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0RLN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000068004; EBBACP00000066241; EBBACG00000067995.
GeneID4543702.
GenomeReviewsGene locus BALH_4963 in contig CP000485_GR.
KEGGbtl:BALH_4963.
PATRIC19003050. VBIBacThu63319_5495.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
GeneTreeEBGT00050000000995.
HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycBTHU412694:BALH_4963-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR001295. Dihydroorotate_DH_CS.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_BACAH
AccessionPrimary (citable) accession number: A0RLN5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents