A0RJR6 (MSCL_BACAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	BALH_4252

Organism

Bacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]

Taxonomic identifier

412694 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_1000015352
Regions
	Transmembrane	14 – 34	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	69 – 89	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A0RJR6 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 8B8D0C1DF89BCE58	FASTA	132	14,751
	10 20 30 40 50 60 MWNEFKKFAF KGNVIDLAVG VVIGAAFGKI VSSLVKDIIT PLLGMVLGGV DFTGLKITFG 70 80 90 100 110 120 KASIMYGKFI QTIFDFLIIA AAIFMFVKVF NKLTSKREEE KEEELPEPTK EEELLGEIRD 130 LLKQQNSSKD RA

References

[1]

"The complete genome sequence of Bacillus thuringiensis Al Hakam." Challacombe J.F., Altherr M.R., Xie G., Bhotika S.S., Brown N., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Green L.D., Han C.S. , Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., Martinez D., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Gilna P., Brettin T.S. J. Bacteriol. 189:3680-3681(2007) [PubMed: 17337577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Al Hakam.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000485 Genomic DNA. Translation: ABK87459.1.
RefSeq	YP_896966.1. NC_008600.1.
3D structure databases
ProteinModelPortal	A0RJR6.
ModBase	Search...
Protein-protein interaction databases
STRING	A0RJR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000069880; EBBACP00000068117; EBBACG00000069871.
GeneID	4543783.
GenomeReviews	Gene locus BALH_4252 in contig CP000485_GR.
KEGG	btl:BALH_4252.
NMPDR	fig|412694.5.peg.4092.
PATRIC	19001440. VBIBacThu63319_4716.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
GeneTree	EBGT00050000002096.
HOGENOM	HBG727604.
OMA	VIDFVIV.
ProtClustDB	PRK13955.
Enzyme and pathway databases
BioCyc	BTHU412694:BALH_4252-MONOMER.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_BACAH

Accession

Primary (citable) accession number: A0RJR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program